GenomeNet

Database: UniProt
Entry: L8HZK9_9CETA
LinkDB: L8HZK9_9CETA
Original site: L8HZK9_9CETA 
ID   L8HZK9_9CETA            Unreviewed;       276 AA.
AC   L8HZK9;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=Transmembrane ascorbate-dependent reductase CYB561 {ECO:0000256|ARBA:ARBA00024231};
DE   AltName: Full=Cytochrome b-561 {ECO:0000256|ARBA:ARBA00030896};
DE   AltName: Full=Cytochrome b561 {ECO:0000256|ARBA:ARBA00032709};
GN   ORFNames=M91_00466 {ECO:0000313|EMBL:ELR49348.1};
OS   Bos mutus (wild yak).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR49348.1, ECO:0000313|Proteomes:UP000011080};
RN   [1] {ECO:0000313|EMBL:ELR49348.1, ECO:0000313|Proteomes:UP000011080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX   PubMed=22751099; DOI=10.1038/ng.2343;
RA   Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA   Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA   Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA   Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA   Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA   Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA   Wang J., Liu J.;
RT   "The yak genome and adaptation to life at high altitude.";
RL   Nat. Genet. 44:946-949(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-ascorbate(in) + monodehydro-L-ascorbate radical(out) = L-
CC         ascorbate(out) + monodehydro-L-ascorbate radical(in);
CC         Xref=Rhea:RHEA:66524, ChEBI:CHEBI:38290, ChEBI:CHEBI:59513;
CC         Evidence={ECO:0000256|ARBA:ARBA00024163};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66525;
CC         Evidence={ECO:0000256|ARBA:ARBA00024163};
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC         Evidence={ECO:0000256|ARBA:ARBA00001970};
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle,
CC       chromaffin granule membrane {ECO:0000256|ARBA:ARBA00024185}; Multi-pass
CC       membrane protein {ECO:0000256|ARBA:ARBA00024185}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JH882455; ELR49348.1; -; Genomic_DNA.
DR   AlphaFoldDB; L8HZK9; -.
DR   STRING; 72004.ENSBMUP00000033159; -.
DR   Proteomes; UP000011080; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 1.20.120.1770; -; 1.
DR   InterPro; IPR043205; CYB561/CYBRD1-like.
DR   InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM.
DR   PANTHER; PTHR10106; CYTOCHROME B561-RELATED; 1.
DR   PANTHER; PTHR10106:SF14; TRANSMEMBRANE ASCORBATE-DEPENDENT REDUCTASE CYB561; 1.
DR   Pfam; PF03188; Cytochrom_B561; 1.
DR   SMART; SM00665; B561; 1.
DR   PROSITE; PS50939; CYTOCHROME_B561; 1.
PE   4: Predicted;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW   Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00022617};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        72..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        107..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        140..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          41..245
FT                   /note="Cytochrome b561"
FT                   /evidence="ECO:0000259|PROSITE:PS50939"
SQ   SEQUENCE   276 AA;  30010 MW;  78561472B35B9410 CRC64;
     MWRILTCTLT AGGSAASSRL SMEGPASPAR APGALPYYVA FSQLLGLIVV AMTGAWLGMY
     RGGIAWESAL QFNVHPLCMI IGLVFLQGDA LLVYRVFRNE AKRTTKVLHG LLHVFAFVIA
     LVGLVAVFEH HRKKGYADLY SLHSWCGILV FALFFAQVSP RVPTVAGRGR EQGPNRLRPA
     PPPGGSVRCG RAGAFLRLGG RALGLRATPQ PRRTKYSMFE PEGVLANVLG LLLATFATVI
     LYILTRADWK RPLQAEEQAL SMDFKTLTEG DSPSSQ
//
DBGET integrated database retrieval system