ID L8I0Z3_9CETA Unreviewed; 221 AA.
AC L8I0Z3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Cytotoxic T-lymphocyte protein 4 {ECO:0000256|ARBA:ARBA00016331};
DE AltName: Full=Cytotoxic T-lymphocyte-associated antigen 4 {ECO:0000256|ARBA:ARBA00032097};
GN ORFNames=E5288_WYG000606 {ECO:0000313|EMBL:MXQ79186.1}, M91_06413
GN {ECO:0000313|EMBL:ELR50165.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR50165.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR50165.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080}, and YakQH1
RC {ECO:0000313|EMBL:ELR50165.1};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
RN [2] {ECO:0000313|EMBL:MXQ79186.1, ECO:0000313|Proteomes:UP000322234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WY2019 {ECO:0000313|EMBL:MXQ79186.1};
RC TISSUE=Blood {ECO:0000313|EMBL:MXQ79186.1};
RA Liu Y.;
RT "The sequence and de novo assembly of the wild yak genome.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibitory receptor acting as a major negative regulator of
CC T-cell responses. The affinity of CTLA4 for its natural B7 family
CC ligands, CD80 and CD86, is considerably stronger than the affinity of
CC their cognate stimulatory coreceptor CD28.
CC {ECO:0000256|ARBA:ARBA00002230}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; JH882248; ELR50165.1; -; Genomic_DNA.
DR EMBL; VBQZ03000001; MXQ79186.1; -; Genomic_DNA.
DR RefSeq; XP_005904340.1; XM_005904278.1.
DR AlphaFoldDB; L8I0Z3; -.
DR SMR; L8I0Z3; -.
DR STRING; 72004.ENSBMUP00000025202; -.
DR Ensembl; ENSBMUT00000029018; ENSBMUP00000025202; ENSBMUG00000018913.
DR GeneID; 102281370; -.
DR KEGG; bom:102281370; -.
DR CTD; 1493; -.
DR OrthoDB; 4108912at2759; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR Proteomes; UP000322234; Unassembled WGS sequence.
DR GO; GO:0045334; C:clathrin-coated endocytic vesicle; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0098636; C:protein complex involved in cell adhesion; IEA:Ensembl.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0045590; P:negative regulation of regulatory T cell differentiation; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0042129; P:regulation of T cell proliferation; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR008096; CTLA4.
DR InterPro; IPR040216; CTLA4/CD28.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR11494; CYTOTOXIC T-LYMPHOCYTE PROTEIN; 1.
DR PANTHER; PTHR11494:SF8; CYTOTOXIC T-LYMPHOCYTE PROTEIN 4; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01720; CTLANTIGEN4.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 160..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..130
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 221 AA; 24433 MW; 2CAF148422C597AA CRC64;
MACSGFQSHG TWWTSRTWPC TALFFLVFIP VFSKGMNVTQ PPVVLASSRG VASFSCEYES
SGKADEVRVT VLREAGSQVT EVCAGTYMVE DELTFLDDST CIGTSRGNKV NLTIQGLRAM
DTGLYVCKVE LMYPPPYYVG IGNGTQIYVI DPEPCPDSDF LLWILAAVSS GLFFYSFLIT
AVSLSKMLKK RSPLTTGVYV KMPPTEPECE KQFQPYFIPI N
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