ID L8I2L7_9CETA Unreviewed; 465 AA.
AC L8I2L7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Kunitz-type protease inhibitor 1 {ECO:0000313|EMBL:ELR50356.1};
DE Flags: Fragment;
GN ORFNames=M91_00930 {ECO:0000313|EMBL:ELR50356.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR50356.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR50356.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
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DR EMBL; JH882202; ELR50356.1; -; Genomic_DNA.
DR AlphaFoldDB; L8I2L7; -.
DR STRING; 72004.ENSBMUP00000024317; -.
DR MEROPS; I02.008; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd22623; Kunitz_HAI1_1-like; 1.
DR CDD; cd22624; Kunitz_HAI1_2-like; 1.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR013980; MANSC_dom.
DR InterPro; IPR011106; MANSC_N.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR PANTHER; PTHR46750; KUNITZ-TYPE PROTEASE INHIBITOR 1; 1.
DR PANTHER; PTHR46750:SF1; KUNITZ-TYPE PROTEASE INHIBITOR 1; 1.
DR Pfam; PF00014; Kunitz_BPTI; 2.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF07502; MANEC; 1.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00765; MANEC; 1.
DR SUPFAM; SSF57362; BPTI-like; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 2.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50986; MANSC; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 402..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..76
FT /note="MANSC"
FT /evidence="ECO:0000259|PROSITE:PS50986"
FT DOMAIN 186..236
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 327..377
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DISULFID 271..283
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 278..296
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 290..305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELR50356.1"
SQ SEQUENCE 465 AA; 52462 MW; 4B084F18B935F2F8 CRC64;
TDASVRNGAT FLRSLTARRG RDCVHACCSS NDCNLALVEL QPDGGEDAIV SCFLINCLYE
QNFVCKFAPR EGFINYLTRE VYRSYRELRT QGFRGSRIPM AWDGIDLKVQ PQEPLVLKGV
ENTDWRLLRG DTDIRVERND PDQVELWGLK DGSYLFQLTA TGSDQPERTS NVTVTVLSPE
QTEEYCLASR KVGRCRGSFP RWYYDPTEQI CKSFVYGGCL GNKNNYLREE ECKLACRNVQ
GGPLRSSVGA QVTFPQGPSA ERHHPVCSGS CHSSKFRCAD GCCIDSFLEC DDTPDCPDAS
DEATCEKYTR DFDKLQRIHF PGDKGHCVDM PDTGLCSESI PRWYYNPFTE HCARFTYGGC
YGNKNNFEEE EQCLESCRGI SKKDVFGLRR ESPVPNTGPV EVAIAVLLGT CIVVVVAILG
YCFFKNQRKD FHRHRHPPPS TPTSSKVSTT DDMEHLVYYQ TTRPL
//
