ID   L8I695_9CETA            Unreviewed;       242 AA.
AC   L8I695;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=small monomeric GTPase {ECO:0000256|ARBA:ARBA00011984};
DE            EC=3.6.5.2 {ECO:0000256|ARBA:ARBA00011984};
DE   Flags: Fragment;
GN   ORFNames=M91_00439 {ECO:0000313|EMBL:ELR51718.1};
OS   Bos mutus (wild yak).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR51718.1, ECO:0000313|Proteomes:UP000011080};
RN   [1] {ECO:0000313|EMBL:ELR51718.1, ECO:0000313|Proteomes:UP000011080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX   PubMed=22751099; DOI=10.1038/ng.2343;
RA   Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA   Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA   Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA   Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA   Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA   Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA   Wang J., Liu J.;
RT   "The yak genome and adaptation to life at high altitude.";
RL   Nat. Genet. 44:946-949(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00023421};
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC       {ECO:0000256|ARBA:ARBA00008344}.
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DR   EMBL; JH881902; ELR51718.1; -; Genomic_DNA.
DR   AlphaFoldDB; L8I695; -.
DR   STRING; 72004.ENSBMUP00000031179; -.
DR   Proteomes; UP000011080; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd04146; RERG_RasL11_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR45704; RAS-LIKE FAMILY MEMBER 11; 1.
DR   PANTHER; PTHR45704:SF3; RAS-LIKE PROTEIN FAMILY MEMBER 11A; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   3: Inferred from homology;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011080}.
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ELR51718.1"
FT   NON_TER         242
FT                   /evidence="ECO:0000313|EMBL:ELR51718.1"
SQ   SEQUENCE   242 AA;  26899 MW;  6EBDDB07125A24DC CRC64;
     VRPPTMSGHF LLAPIPESSS DYLLPKDIKL AVLGAGRVGK SAMIVRFLTK RFIGDYEPNT
     GKLYSRLVYV EGDQVSLQIQ DTPGGIQVQD SLVQAGDPLS KCVQWAEGFL LVYSITDYDS
     YLAIRPLHQH IRKVHPDSRA PIVIVGNKGD LLHARQVQTR EGVQLANELG SLFLEVSTSE
     NYEDVCDAFR HLCREVSKLH NLGSERRRAS VVPRPRSPNM QDLKRRFKQA LSSKAKAPSA
     PA
//