ID L8I7A3_9CETA Unreviewed; 619 AA.
AC L8I7A3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Rho guanine nucleotide exchange factor 25 {ECO:0000313|EMBL:ELR52098.1};
GN ORFNames=M91_11203 {ECO:0000313|EMBL:ELR52098.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR52098.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR52098.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
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DR EMBL; JH881817; ELR52098.1; -; Genomic_DNA.
DR RefSeq; XP_005901740.1; XM_005901678.2.
DR AlphaFoldDB; L8I7A3; -.
DR STRING; 72004.ENSBMUP00000034267; -.
DR Ensembl; ENSBMUT00000039422; ENSBMUP00000034266; ENSBMUG00000025517.
DR GeneID; 102281644; -.
DR KEGG; bom:102281644; -.
DR CTD; 115557; -.
DR OrthoDB; 2906033at2759; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13241; PH2_Kalirin_Trio_p63RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22826:SF117; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011080}.
FT DOMAIN 199..375
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 387..505
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 25..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..606
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 619 AA; 68112 MW; F7A2FC74CC61A32F CRC64;
MKPPDRPGPG RTDRILGVMG GMLRACALPG QEGPSKRSPL GPGSTEPGSN CTEGDQRGES
DREVPAWVPL LESYSIAGSE GSISASAASG LAAPSGPSSG LSSGPCSPGP PRPVSGLRRW
LDHSKHCLSV ETEADSGRAG PYENWMLEPA LATGEELPEL NLLTTLLGGP GDKTQPPEEE
TLSQAPESEE EQKKKALERS MYVLSELVET EKMYVDDLGQ IVEGYMATMA AQGVPENLRG
RDRIVFGNIQ QIYEWHRDYF LRELQRCLKD PDWLAQLFIK HERRLHMYVV YCQNKPKSEH
VVSEFGDSYF EELRQQLGHR LQLNDLLIKP VQRIMKYQLL LKDFLKYYRR AGMDTEELEQ
AVEVMCFVPK RCNDMMTLGR LRGFEGKLTA QGKLLGQDTF WVTEPEAGGL LSSRGRERRV
FLFEQIIIFS EALGGGVRGG AQPGYVYKNS IKVSCLGLEV NLQGDPCRFA LTSRGPEGGI
QRYVLQAADP AISQAWIKQV AQMLESQRDF LNALQSPIEY QRRESQTNSL GRPGGPGVGS
PGRIRPGDRA QLSTHTPING SLPSLLLSPK GEVARAPLRL DTQAPSAIPQ APHDSPPVPP
IPDTPPCQAR LAKLDEDEL
//
