ID   L8IBR5_9CETA            Unreviewed;       562 AA.
AC   L8IBR5;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Bifunctional coenzyme A synthase {ECO:0000313|EMBL:ELR53920.1};
GN   ORFNames=M91_17134 {ECO:0000313|EMBL:ELR53920.1};
OS   Bos mutus (wild yak).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR53920.1, ECO:0000313|Proteomes:UP000011080};
RN   [1] {ECO:0000313|EMBL:ELR53920.1, ECO:0000313|Proteomes:UP000011080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX   PubMed=22751099; DOI=10.1038/ng.2343;
RA   Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA   Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA   Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA   Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA   Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA   Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA   Wang J., Liu J.;
RT   "The yak genome and adaptation to life at high altitude.";
RL   Nat. Genet. 44:946-949(2012).
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DR   EMBL; JH881506; ELR53920.1; -; Genomic_DNA.
DR   AlphaFoldDB; L8IBR5; -.
DR   STRING; 72004.ENSBMUP00000021006; -.
DR   Ensembl; ENSBMUT00000024222; ENSBMUP00000021006; ENSBMUG00000015802.
DR   Proteomes; UP000011080; Unassembled WGS sequence.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:Ensembl.
DR   GO; GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IEA:Ensembl.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:Ensembl.
DR   CDD; cd02022; DPCK; 1.
DR   CDD; cd02164; PPAT_CoAS; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR001977; Depp_CoAkinase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR   PANTHER; PTHR10695:SF64; BIFUNCTIONAL COENZYME A SYNTHASE; 1.
DR   PANTHER; PTHR10695; DEPHOSPHO-COA KINASE-RELATED; 1.
DR   Pfam; PF01121; CoaE; 1.
DR   Pfam; PF01467; CTP_transf_like; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51219; DPCK; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..562
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003991673"
FT   DOMAIN          195..337
FT                   /note="Cytidyltransferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF01467"
SQ   SEQUENCE   562 AA;  61800 MW;  E0B6A8C828E0D376 CRC64;
     MAVFRSGLLV LTTPLTSLAP RLAPILSSAA RLVNHTLYVH LQPGMSLGGP AQPQSSPVQA
     TFEVLDFITH LYAGADVHRH LDVRILLTNI RTKSCLPPLP TSVQNLAHPP EVVLTDFQTL
     DGSQYNPAKQ QLERYATSCY SCCPKLSSVL LYPDYGPAVS PAGSLGVHLP STIRPTSPVA
     RSAKQPVRGH QRGAVGGTFD RLHNAHKVLL SVACILAQEQ LVVGVADKDL LKSKLLPELL
     QPYTERVEHL SEFLVDIKPS LTFDIIPLLD PYGPAGSDPS LEFLVVSEET YRGGMAVNRF
     RLENDLEELT LYQIQLLKDL NHKENEEDKV SSSSFRQQML GNLLRPPYKR PELPPGFYVI
     GLTGISGSGK SSVAQRLKGL GAYIIDSDHL GHRAYAPGGP AYQPVVEAFG TDILHKDGII
     NRKVLGSRVF GNKKQLKILT DIMWPVIAKL AREEMDQAVA EGKRVCVIDA AMLLEAGWQN
     MVHEVWTVVI PETEAIRRIM ERDGLSEAAA QSRLQSQMSG QQLVDQSHVV LSTMWEPHVT
     QRQVEKAWAL LQKRISEAPS GP
//