ID L8ID44_9CETA Unreviewed; 1167 AA.
AC L8ID44;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Integrin alpha-10 {ECO:0000313|EMBL:ELR54410.1};
GN ORFNames=M91_04793 {ECO:0000313|EMBL:ELR54410.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR54410.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR54410.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; JH881426; ELR54410.1; -; Genomic_DNA.
DR RefSeq; XP_005898577.1; XM_005898515.1.
DR AlphaFoldDB; L8ID44; -.
DR STRING; 72004.ENSBMUP00000008818; -.
DR Ensembl; ENSBMUT00000010278; ENSBMUP00000008818; ENSBMUG00000006839.
DR GeneID; 102287332; -.
DR KEGG; bom:102287332; -.
DR CTD; 8515; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0034680; C:integrin alpha10-beta1 complex; IEA:Ensembl.
DR GO; GO:0098639; F:collagen binding involved in cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF26; INTEGRIN ALPHA-10; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 23..1167
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5001425279"
FT TRANSMEM 1121..1145
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 24..85
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 167..350
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 472..534
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 535..593
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 597..657
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1167 AA; 127880 MW; 0E6740913947ED11 CRC64;
MEFPLIPHLF LPLMFLTGLC SSFNLDVHRP RLFLGPPEAE FGYSVLQHVG GGRQWMLVGA
PWDGPSGDRR GDVYRCLVGG SHSAPCAKGH LGDHPLGNSS RPAVNMHLGM SLLETDGNGG
FMACAPLWSR ACGSSVFSSG ICARVDASFR PQGSLAPTAQ RCPTYMDVVI VLDGSNSIYP
WSEVQTFLRR LVGRLFIDPE QIQVGLVQYG ESSVHEWSLG DFRTKEEVVR AARNLSRREG
RETKTAQAIM MACTEGFSQS RGGRPEAARL LVVVTDGESH DGEELPTALQ ACEAGRVTRY
GIAVLGHYLR RQRDPSSFLR EIRAIASDPD EKFFFNVTDE AALTDIVDAL GDRIFGLEGS
HGENESSFGL EMSQIGFSTH QLKDGILFGM VGAYDWGGSV LWLEEGRRLF PPRTALEDEF
PPALQNHAAY LGYSVSSMFL RGGRRLFLSG APRFSHRGKV IAFQLKKDGA VRVAQSLQGE
QIGSYFGSEL CPLDIDGDGT TDVLLVAAPM FLGPQNKETG RVYVYLVGQP SLLTLQRTLQ
PESPQDARFG FAMGALPDLN QDGFADVAVG APLEDGHRGA LYLYHGAQRG VRPRPAQRIA
AVAMPQALSY FGRSVDGRLD LDGDDLVDVA VGAQGAAILL SSRPIVRLAP SLDVTPPAIS
VVQRDCKRRG QEATCLSAAL CFQVTSRTPG HWDRRFHVRF TASLDEWTTA ARAAFDGSGQ
RLSPRQLRLS VGNITCEQLH FHVLDTSDYL RPVSLTVTFA LDNTTKPGPV LDEGSPTSIQ
KLVPFSKDCG PDNECVTDLV LQANMDIRGS RKDPFVVRGG RRKVLVSATL ENKKENAYNT
SLSLNFSRNL HLSSFTPQSN SPVKVECAAP TPHTRLCSVG HPVFQTGAKV TFLLEFEFSC
SFLLSQVLVR LTATSSSLER NGTLRDNTAQ TSAYIQYEPY LLFSSESTLH RYEVHPYGTL
PVGPGPEFKT TLRVQNLGCY VVSGLIVSAL LPAVAYGGNY FLSLSQVITN NASCTVQNLT
EPPGPPVHPE ELQHTSRLNE SNTRCQVVRC HLGRLAKGTE ISVGLLRLVH NEFFRRAKFK
SLTVVSTFEL STEEGSVLLL TEASRWSESL LEVIQSRPVL ISLWILIGSV LGGLLLLSLL
VFCLWKLGFF ARKKIPEEEK REDKLEQ
//
