ID L8IF73_9CETA Unreviewed; 1153 AA.
AC L8IF73;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Activating signal cointegrator 1 complex subunit 3 {ECO:0000256|ARBA:ARBA00014590};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=M91_18160 {ECO:0000313|EMBL:ELR54184.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR54184.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR54184.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; JH881463; ELR54184.1; -; Genomic_DNA.
DR RefSeq; XP_005898880.1; XM_005898818.2.
DR AlphaFoldDB; L8IF73; -.
DR STRING; 72004.ENSBMUP00000024247; -.
DR GeneID; 102286965; -.
DR KEGG; bom:102286965; -.
DR CTD; 57647; -.
DR OrthoDB; 5490433at2759; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ELR54184.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ELR54184.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080}.
FT DOMAIN 258..425
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 544..712
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1153 AA; 128664 MW; 8EE2270FB98C3D6F CRC64;
MGKLRRRYNI KGRQQTAPGT SKGPPEPPPV RLELEDKDTL KGVDASNALV LPGKKKKKTK
APPLSKKEKK PLTKKERKML QRILDQKEKK SQRAEMLQKL SEVQVSEAEM RLFYTTSKLG
TGERMYHTKE KPDDVAAQGS EKISSLSGAH RKRRRQEAEE ESESSVDSEP EEAPTDNRSE
ASAGSAPAHV PPAPSGARGQ NPAPSGPAET PAPPAATPTA ASALVRPPSK PAVFLPRSPE
MQVGRSSLPI LSEEQVIMEA VAEHPIVIIC GETGSGKTTQ VPQFLYEAGY SSDNSIIGVT
EPRRVAAVAM SQRVAKEMNL SPRVVSYQIR YEGNVTEETR IKFMTDGVLL KEIQKDFLLL
KYKVVIIDEA HERSVYTDIL IGLLSRIVCL REKRHLPLKL LIMSATLRVE DFTQNQRLFT
QPPPVIKVES RQFPVTVHFN KRTPLEDYSG ECFRKVCKIH RMLPAGGILV FLTGQAEVHA
LCRRLRRAFP LTRHRPPEKD DQRDSVEETR RFKKSRARAK KAQAMTLPQI SLDSYSVLPA
GEGDEDREAE MDDEEEAALG SDLDLDLGDH GADGGEQPDA CLPLHVLPLY SLLAPEKQAQ
VFQPPPEGTR LCVVATNVAE TSLTIPGIKY VVDCGKAKKR HYDRVTGVSS FRVTWVSQAS
ADQRAGRAGR TEPGHCYRLY SSAVFGDFEK YPPPEITRRP VEDLILQMKA LNIEKVINFP
FPTPPSVEAL IAAEELLIAL GALQAPPKTE RVKQLQRSRL SCPITELGRT MATFPVAPRY
AKMLALSRQH GCLPYTITIV AAMTVRELFE ELDRPAASDE ELARLKGKRA RVAQMKRIWA
GQGASLKLGD LMVLLGAVGA CEYAGCSPQF CEANGLRYKA MMEIRRLRGQ LTTAANAMCP
EAGLFVDPKM QPPNEDQVTY LRQVVTAGLG DHLARKVRSE DLVDDKWRNA YKTPLLDDPV
FIHPSSVLFK ELPEFVVYQE IVETTKMYMK GVSTVDMQWI PVLLPSYCQF DKPLEEPPPA
YCPEKGRMLC HRASVFYRVG WPLPAVQVDF PEGLDCYKHF ARVLLEGQVF PKLASYKGCL
LSSPSTMLKT WARLQPRTES LLRALVAKKA NCRDALLVAW SKNPKYLLTE YLEWLPQAVH
TDVEKAWPPT RDH
//
