ID L8IP66_9CETA Unreviewed; 405 AA.
AC L8IP66;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Pleckstrin homology domain-containing family O member 1 {ECO:0000256|ARBA:ARBA00019333};
DE Flags: Fragment;
GN ORFNames=M91_14437 {ECO:0000313|EMBL:ELR56932.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR56932.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR56932.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JH881048; ELR56932.1; -; Genomic_DNA.
DR AlphaFoldDB; L8IP66; -.
DR STRING; 72004.ENSBMUP00000031296; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd13317; PH_PLEKHO1_PLEKHO2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR043448; PKHO1/2.
DR PANTHER; PTHR15871; PH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15871:SF1; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY O MEMBER 1; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080}.
FT DOMAIN 17..128
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 214..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELR56932.1"
SQ SEQUENCE 405 AA; 45796 MW; DFFC24EE2F533811 CRC64;
SDSRGQGPQD GNHQCAPPEK VGWVRKFCGK GIFREIWKNR YVVLKGDQLY ISEKEVKDEK
NIQEVFDLSD YEKCEELRKS KSRSKKNHSK FTLAHSKQPG NTAPNLIFLA VSPEEKESWI
NALNSAITRA KNRVLDEVTV EEDSYLAHPT RDRAKIQHSR RPPTRGHLMA VASTSTSDGM
LTLDLIQEED PSPEEPTSCA ESFRVDLDKS VAQLAGSRRR ADSDRIQPSS DRASGLPRLW
EKPDKGATYT PQAPKKLTAT EKSRCASLEE ILSQRDAVPA HTLQRRAEDS PTPIPHAPGQ
LSRIQDLVAR KLEKTQELLA EVQGLGDGKR KAKEPPRSPP DSESEQLLLE TERLLGEASS
NWSQAKRVLQ EVRELRDLYR QMDLQTPDSH LRQTTQHSQY RKSLM
//
