ID L8IPR7_9CETA Unreviewed; 651 AA.
AC L8IPR7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Interferon-induced GTP-binding protein Mx1 {ECO:0000256|ARBA:ARBA00039833};
DE AltName: Full=Myxoma resistance protein 1 {ECO:0000256|ARBA:ARBA00043055};
DE AltName: Full=Myxovirus resistance protein 1 {ECO:0000256|ARBA:ARBA00042029};
GN ORFNames=M91_11734 {ECO:0000313|EMBL:ELR58321.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR58321.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR58321.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR EMBL; JH880856; ELR58321.1; -; Genomic_DNA.
DR RefSeq; XP_005893079.1; XM_005893017.2.
DR AlphaFoldDB; L8IPR7; -.
DR STRING; 72004.ENSBMUP00000025239; -.
DR GeneID; 102273400; -.
DR KEGG; bom:102273400; -.
DR CTD; 4599; -.
DR OrthoDB; 1052588at2759; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF217; INTERFERON-INDUCED GTP-BINDING PROTEIN MX1; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU003932};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080}.
FT DOMAIN 59..332
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 563..651
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
SQ SEQUENCE 651 AA; 75357 MW; 6691E0EC31EB52DE CRC64;
MLGVMGGRRR RGRRRMRCLD GITDSMDEPK SNLYSQYEEK VRPCIDLIDS LRSLGVEQDL
ALPAIAVIGD QSSGKSSVLE ALSGVALPRG SGIVTRCPLV LRLKKLGNED EWKGKVSFLD
KEIEIPDASQ VEKEISEAQI AIAGEGTGIS HELISLEVSS PHVPDLTLID LPGITRVAVG
NQPPDIEYQI KSLIRKYILR QETINLVVVP ANVDIATTEA LHMAQEVDPQ GDRTIGILTK
PDLVDKGTED KVVDVVRNLV FHLKKGYMIV KCRGQQDIKH RMSLDKALQR ERIFFEDHAH
FRDLLEEGKA TIPCLAERLT SELIMHICKT LPLLENQIKE THQRITEELQ KYGKDIPEEE
SEKMFCLIEK IDTFNKEIIS TIEGEEFVEQ YDSRLFTKVR AEFSKWSAVV EKNFEKGYEA
IRKEIKQFEN RYRGRELPGF VNYKTFETII KKQVRVLEEP AVDMLHTVTD IIRNTFTDVS
GKHFNEFFNL HRTAKSKIED IRLEQENEAE KSIRLHFQME QLVYCQDQVY RRALQQVREK
EAEEEKNKKS NHYFQSQVSE PSTDEIFQHL TAYQQEVSTR ISGHIPLIIQ FFVLRTYGEQ
LKKSMLQLLQ DKDQYDWLLK ERTDTRDKRK FLKERLERLT RARQRLAKFP G
//
