ID L8ISC1_9CETA Unreviewed; 817 AA.
AC L8ISC1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Tax1-binding protein 1-like protein {ECO:0000313|EMBL:ELR59475.1};
GN ORFNames=M91_02174 {ECO:0000313|EMBL:ELR59475.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR59475.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR59475.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome
CC {ECO:0000256|ARBA:ARBA00004419}. Preautophagosomal structure
CC {ECO:0000256|ARBA:ARBA00004329}.
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DR EMBL; JH880712; ELR59475.1; -; Genomic_DNA.
DR RefSeq; XP_005891494.1; XM_005891432.2.
DR AlphaFoldDB; L8ISC1; -.
DR SMR; L8ISC1; -.
DR STRING; 72004.ENSBMUP00000026389; -.
DR Ensembl; ENSBMUT00000030384; ENSBMUP00000026389; ENSBMUG00000019787.
DR Ensembl; ENSBMUT00000030390; ENSBMUP00000026394; ENSBMUG00000019787.
DR GeneID; 102276345; -.
DR KEGG; bom:102276345; -.
DR CTD; 8887; -.
DR OrthoDB; 3062393at2759; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0000407; C:phagophore assembly site; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0039532; P:negative regulation of cytoplasmic pattern recognition receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR GO; GO:1905161; P:protein localization to phagocytic vesicle; IEA:Ensembl.
DR CDD; cd21969; Zn-C2H2_TAX1BP1_rpt1; 1.
DR CDD; cd21970; Zn-C2H2_TAX1BP1_rpt2; 1.
DR Gene3D; 2.60.40.2840; -; 1.
DR Gene3D; 6.20.250.40; -; 1.
DR InterPro; IPR012852; CALCOCO1-like.
DR InterPro; IPR041641; CALCOCO1/2_Zn_UBZ1.
DR InterPro; IPR041611; SKICH.
DR PANTHER; PTHR31915; SKICH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR31915:SF8; TAX1-BINDING PROTEIN 1; 1.
DR Pfam; PF07888; CALCOCO1; 1.
DR Pfam; PF17751; SKICH; 1.
DR Pfam; PF18112; Zn-C2H2_12; 2.
DR PROSITE; PS51905; ZF_UBZ1; 2.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01253}.
FT DOMAIN 755..781
FT /note="UBZ1-type"
FT /evidence="ECO:0000259|PROSITE:PS51905"
FT DOMAIN 782..808
FT /note="UBZ1-type"
FT /evidence="ECO:0000259|PROSITE:PS51905"
FT REGION 609..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 154..307
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 349..376
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 402..469
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 545..597
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 609..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 817 AA; 94059 MW; 5293ED0CB703F092 CRC64;
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA
RDYYTFLWSP MPEHYVEGSA VNCELAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF
RAASPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETTQLRE
QVGRMERELN HEKERGDQLQ AEQKALTKVS QSLKMENEEF KKRYNDVTSK ALQLEEDIVS
VTHKAIEKET ELDSLKDKLK KAQCEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLVSE
VQTLKNLDGN KENMITHFKE EISRLQFSLA EKENLQRTFL LTTSSKEDTF ILKEQLRKAE
EQIQATRQEA VFLAKELSDA VNVRDKTMAD LHTAHLENEK VKKQLTDALA ELKLSAVNKD
QEKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANSNSVFTKK
IGSQQKVNDA SINTDPAATA STVDVKPLPS TAETDFDNLT KGQVSEMTKE IADKTEKYNK
CKQLLQDEKT KCNKYADELA KMELKWKEQV KIAENIKLEL AEVVDNYKLQ LAEKEKEISG
LTSYWENLSR EKEHKRSVEN QAERKLEGQN SQSPHQISQC LKTSSEKSGH VPAVSNTQPV
LQYGNPYATP ETRDGADGAF YPDEIQRPPV RVPSWGLEDN VVCSQPARNL SRPDGLEDPE
DSKEDEKVPT APDPPSQHLR GHGTGFCFDP SFDVQKKCPL CELMFPPNYD QSKFEEHVES
HWKVCPMCSE QFPPDYDQQV FERHVQTHFD QNVLNFD
//
