ID L8IUH1_9CETA Unreviewed; 3626 AA.
AC L8IUH1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Cubilin {ECO:0000313|EMBL:ELR59114.1};
DE Flags: Fragment;
GN ORFNames=M91_19471 {ECO:0000313|EMBL:ELR59114.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR59114.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR59114.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; JH880756; ELR59114.1; -; Genomic_DNA.
DR STRING; 72004.ENSBMUP00000011142; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 27.
DR CDD; cd22201; cubilin_NTD; 1.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 27.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF37; CUB DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 27.
DR Pfam; PF00008; EGF; 4.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR SMART; SM00042; CUB; 27.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 7.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 27.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01180; CUB; 27.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..3626
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003992236"
FT DOMAIN 132..168
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 170..211
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 263..304
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 349..385
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 395..430
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 432..468
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 474..586
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 590..702
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 708..815
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 816..927
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 931..1041
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1047..1161
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1165..1277
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1278..1389
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1391..1506
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1510..1619
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1623..1737
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1741..1853
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1855..1966
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1981..2094
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2095..2216
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2220..2337
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2339..2451
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2455..2568
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2573..2690
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2692..2804
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2808..2922
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2923..3038
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3040..3153
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3160..3277
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3281..3398
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3398..3510
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3514..3626
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT COILED 110..137
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 158..167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 201..210
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 399..409
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 420..429
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 458..467
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1623..1650
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 2339..2366
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 3040..3067
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT NON_TER 3626
FT /evidence="ECO:0000313|EMBL:ELR59114.1"
SQ SEQUENCE 3626 AA; 396706 MW; A9326E65A2D59767 CRC64;
VRNMSSLFLG SLVILLTFAA SYSEDGGFAL QRQKRNIDLQ QPRMTAERGN LVFLTGSAQN
IEFRTGSLGR IKLNDEDVGE CFHQIQKNKD DITNLKRTTV GLPQNISNQI HQLDSKLADL
ERKLQSLQQT LDRKVCSSNP CQHGGTCLNL PDSFFCMCPS QWKGPLCSVD VNECEIYSGT
PLGCQNGATC INTAGSYSCL CSPETHGPQC ASKYDDCEGG SKARCVHGIC EDLVRVKAGE
PEYSCICDAG WKAPSNSTAC TLDVDECNLW PAPCSELVRC FNTPGSFYCG ACPTGWQGNG
YICEDINECE INNGGCSVAP LVECINTHGS YHCHSCPPGY QGDGRVCTLI DRCSVNNGGC
HPQASCSLAL GSLPLCTCLP GYTGNGYGPN GCVQLSNICL SRPCVNGQCI ETVSGYVCKC
ESGWTGVNCT ENINECLSNP CLNGGTCVDG VNAFSCECTH FWTGFLCHIP QEVCGESLSG
MNGSFSFVSP DVAYAHDINC FWVIRTEEGK VLRITFTFFQ LEPTNNCPHE FLQIHDGDSS
AAHQLGRFCG SSPPHELLSS DNALYFHLYS EHLRSERGFT IRWETQLPEC GGMLTGTYGS
IKSPGYPGKY PPGRDCVWRV ITSPDLLITF TFGTLSLEHH DDCSKDYLEI RDGPLHQDPV
LGKFCTTLSA PPLQTTGPFA RIHFHSDNEI NDQGFLITYL TSPLDLQCGG NYTDPEGLLF
ADLSGPFMHD RQCIYTIKQP PGEQIQVNFT VVELEGQSGC SHSYIEVRDD QTLLGKVCGN
ETLSHIKSIT NSIWIRLKMD ASVVRASFSA VYQVACGGEL TGEGIIRSPF YPNVYPGERV
CVWTIRQPQS QVVLLNFTAF DMGGSAHCDT DYVEVGSSSI LGSLKNEKHC GADIPSFITS
VYNSLHVIFV KSSSADNHGF VAEFSSAALA CGKVLTESTG SIQSPGHPNI YPHGISCTWH
IIVQPGHLIH LRFREFHLEF HYNCTKDYLE VYDTGSQTSL GRYCGKSIPP SLTSNDNSVR
LTFVADSDLA YEGFLINYEA TDASAACLND YTEESGTFTS PNFPGFYPNN LECIYRITVE
SSQQIALHFT NFSLEDAIGS TCVADYVEIR NGGYENSPLL GQYCGSNLPP RIISHSNKLW
LKFKSDFFGS GPGFSAYWDG SLTGCGGNLT TSTGTFTSPN YPMPYYHSSE CSWWLKASRG
SPFLLEFEDF HLEYHPNCSQ DYLAVYDGSS TSSHLLTRLC GNEKPSVIRS SGDSMSLKLR
TDEGQQGGGF LVKYQQTCDN VVIVNQTYGI LESIHYPNPY SVNQRCNWTI QATTGNTVNY
TFLAFELEYY TNCSTDYLEL YDGPQRMGRF CGTDIPPSGS TTGSKFHVLF YTDGVSHHEK
GFQMQWFIQG CGGELSGDTG SFSSPGYPNR YPANKECIWY IHTAPGSSIQ LTIHDFDVEY
HARCNFDVLE IYGGPDFYSP RIAQLCVQRS SENPMQVSST GNELAIRFKT DSSINGRGFN
VSWRAVPGGC GGIFQAPSGE IHSPNYPSPY RSNTECTWVI QVEKHHRVLL NFTDFDLEPQ
DSCVLAFDGV SSATARLAGV CGRQQLRNPI ISSGNSLFLR FQSGPSRQSR GFRAYFRQGK
FPCGGHFLTD SVDTISSPLF PNNYPSNQNC SWIIQAQPPF NHITLSFSHF GLESSTPCTR
DFVEVLDGSH DDAPLRGRYC GPSLPHPITS FSNALMLKFV SDSTVNFGGF HATYAASTSA
CGGIFHMAEG IFNSPGYPEV YPANVECVWN VVSSPGNQLQ LSFIAFQLEE SQDCSRDFVE
VREGNATGRL VGRYCGNALP LNYSSAVGHI LWIRFVSDGS GTGMGFQAAF ASIFGNDNIV
GTHGKIASPL WPGNYPHNSN YQWIVNVEES QVIHARILEM DMEGTLNCYY DKLKIYDGAG
IHSRLVGTYC GTQTDSFSST GSSLTFQFSS DSSISGRGFL LEWFAMNASV GPLPTIATGA
CGGFLQTGDT PVFLYSPGWP ESYSNGANCM WLIQAPDSTV ELNILSLDIE SHSTCSYDKL
VIRDGDNSMA QELAVLCGRE VPGPIRSTGE YMVIHFTSDF SVTGAGFNAS FHKSCGGYLH
ADRGIITSPR YPETYTPNLN CSWHVQVQSG LTIAVHFEQP FQILNRDSSC NQGDYLVLKN
GPDLSSPPLG PHGGNGRFCG SHPSSTLFTS DNQMFVQFIS DNSNEGQGFK ITYEAKSLAC
GGNIYIHNAD STGYVTSPNH PDHYPQHADC IWLIAAPPGK LIRLQFEGQF SIEVTPNCTS
NYLELRDGAD SNAPILSKFC GTSLPISQLS SGEVMYLRFR SDNSPTHVGF KAKYSIAPCG
GAVTGQSGVI ESNGYPTQPY TDDLFCEWRL RGPLGHYLTI HFEDFNLQNS SGCERDFVEI
WENHTSGTLL GRYCGSSIPS SIDTSSNVAL VRFVTDGSVS ASGFRLRFDS SLEACGGDLQ
GPSGTFTSPN YRSPNPHGWM CEWRITVQEG RRVTLTFDSL RLEPHPLCSS EHVTVFNGIR
SNSPQLEKLC RSVNGSNEIE SSGNTMKVVY FTDGSRPYGG FIASYTSNED AVCGGSLTSF
PKGNFTSPGY DGVSNYSRNL NCEWMLSNPN QGNSSIYIHF EDFYLETHQD CQSDVLEFRV
DNADGLLIWR LCGSSKPRMP LVIPYPEVWI HFVTDERVEH VGFHAQYSFT DCGGIQIGDS
GVISSPNYPA AYDSLTHCSW LLEAPQGHTI NLTFSDFDVE AHENCAWDSV TVRNGGSPGS
PIIGHYCGIL NPGTIQSGSN QLVVIFNTDH SIQHGGFYAT WSSETLGCGG VLHLNNGTIR
SPHWPQNFPE NSRCSWTVIT HQSKHLEISF DNNFLIPSGD GQCQNSFVKV WGDTQESSQT
LLATSCGNVA PRPITTPRNV FTAVFQSQEA PAQGFSASFV SRCGGNFTSP SGYIVSPNYP
KQYDNNMNCT YIIEASPLSV ILLTLVSFHL EAHSAVTGSC VNDGVHIIRG YSLSSTPLAT
LCGEDSLSPL TTSGPVLLNF YSNAHTTDLG FKFSYRITSC GGVFNLSTGV IKSPLYTYSN
YPDDVHCLYT ITVRSNRVIQ LKFNDFDVVP SASCSEDYLA VYDGSNISDP LLGQFCGSNL
PPNIRSSNNS MFLVFKTDSI QTARGWRITF RQTLGPQQGC GGYLTGSDHS FASPDSDSNG
RYDKGLNCVW FITAPVNKVV KLTFHTFALE AATTLRRCIY DYVKLYDGDS ENANLAGTFC
GSTVPAPFIS SGNFLTVQFV SDLSLEREGF NATYTIMDMP CGGTFNATRT PQSISSPNSS
DPDVPLATCT WVIEAPLHQQ VEITVWAFQL HSQDCNQNYL EFQDPPESNG NPGIRFCGGN
VSAVPTFYSS TSTAVIVFKS EVFSINSRVG FTYKIADCNR EYKKAFGNLR SPGWPSDYAS
DVDCTTVLTA PDNHTISLFF HSFGIEDSSG CTHDFLEVRN GSESSSPLLG TYCGTLLPNP
IFSQSHELYL RFKSDGATSG RGYEIIWTSS PSGCGGTLYG DSGSVTSPGY PGTYPNNTHC
EWAILAPAGR PVTVSFYFIS IDDPGECVQN YLLLYDGPDA NSPSSGPYCG ADTDIAPFVA
SSHRVFIRFH AEYAARPSAL RLTWAS
//
