ID L8IVZ7_9CETA Unreviewed; 597 AA.
AC L8IVZ7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=RUN and FYVE domain-containing protein 4 {ECO:0000313|EMBL:ELR60745.1};
DE Flags: Fragment;
GN ORFNames=M91_13918 {ECO:0000313|EMBL:ELR60745.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR60745.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR60745.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
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DR EMBL; JH880548; ELR60745.1; -; Genomic_DNA.
DR AlphaFoldDB; L8IVZ7; -.
DR STRING; 72004.ENSBMUP00000034733; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0016239; P:positive regulation of macroautophagy; IEA:InterPro.
DR Gene3D; 1.20.58.900; -; 1.
DR InterPro; IPR042939; RUFY4.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR PANTHER; PTHR47732; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR47732:SF1; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02759; RUN; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011080}.
FT DOMAIN 33..166
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 177..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 442..501
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 231..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 597
FT /evidence="ECO:0000313|EMBL:ELR60745.1"
SQ SEQUENCE 597 AA; 66956 MW; 70DCF8564A4A3E1C CRC64;
MAKEGAVLKM TRDLKAAVSA ILQGYGAGQQ PVTDTSAELH RLCGCLELLL QFDQKEQKSF
LRPRKDYWDF LCAALWQQRG DTEPVRFVHS LDKLKTPLGK GRAFIRFCLA HGQLAESLQL
CLLNPEFTRE WYGPRSPLVC PELREDILDS LYALNGMTFD LDLQRPDLDG AWPMFSESHC
SNSSRTRGRR PRKTKESPKE VPLPNLHSSC LFSISVGTPR LKTTYGNSTE VHLEEPHTSQ
ATCLQDAPRK DGLAGLPRSQ QHRHHPHFLE KKKEDPRSLG CPPSMWELDG EEFQLDQEKG
VPRTEICLED STPTIQGQGE GAREPLKEVA GSEAEGKGAL LGVEGQRTTK GTHEGEAERS
HIHRLLASSP KGTIGDVVSW GKHDGKVPSI PGELWILQGL GTKEDSTSEK PQEQTGVTSV
TRREEQAEMA LQDVVKSLRY GLQKTQEQAQ HQEQMLKEQE GELKALQEQL SRCQEERARL
QAELEQKQRE AERKDAVYEE ELGGQRDLVR AMKSRVLELI QEKDILWQKV QHLSSMAPGC
CVVCSKIFGR LSRRYPCRER TVGHQENLPL GGPWKGGAPG HLLGKRRPPE IDPGPSS
//
