ID L8J1Y3_9CETA Unreviewed; 417 AA.
AC L8J1Y3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Procollagen C-endopeptidase enhancer 2 {ECO:0000313|EMBL:ELR61442.1};
GN ORFNames=M91_12294 {ECO:0000313|EMBL:ELR61442.1};
OS Bos mutus (wild yak).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR61442.1, ECO:0000313|Proteomes:UP000011080};
RN [1] {ECO:0000313|EMBL:ELR61442.1, ECO:0000313|Proteomes:UP000011080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yakQH1 {ECO:0000313|Proteomes:UP000011080};
RX PubMed=22751099; DOI=10.1038/ng.2343;
RA Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q., Kim J.,
RA Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A., Qian X., Lang Y.,
RA Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S., Lu X., Hou H., Wang Y.,
RA Zang X., Yin Y., Ma H., Zhang J., Wang Z., Zhang Y., Zhang D., Yonezawa T.,
RA Hasegawa M., Zhong Y., Liu W., Zhang Y., Huang Z., Zhang S., Long R.,
RA Yang H., Wang J., Lenstra J.A., Cooper D.N., Wu Y., Wang J., Shi P.,
RA Wang J., Liu J.;
RT "The yak genome and adaptation to life at high altitude.";
RL Nat. Genet. 44:946-949(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; JH880452; ELR61442.1; -; Genomic_DNA.
DR AlphaFoldDB; L8J1Y3; -.
DR STRING; 72004.ENSBMUP00000027190; -.
DR Proteomes; UP000011080; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR CDD; cd00041; CUB; 2.
DR CDD; cd03576; NTR_PCOLCE; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR035814; NTR_PCOLCE.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR PANTHER; PTHR24251:SF31; PROCOLLAGEN C-ENDOPEPTIDASE ENHANCER 2; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00042; CUB; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059}; Reference proteome {ECO:0000313|Proteomes:UP000011080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..417
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003992641"
FT DOMAIN 34..145
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 155..269
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 299..417
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 155..182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 417 AA; 45805 MW; 3625132E72254681 CRC64;
MRGAGAWAPL CLLLVAAAQH SRPPLSERRP VFTCGGILTG ESGFIGSEGF PGVYPPNSKC
TWKITVPEGK VVVLNFRFID LESDNLCRYD FVDVYNGHAN GQRIGRFCGT FRPGALVSSS
NKMMVQMISD ANTAGNGFMA MFSAAEPNER GDQYCGGLLE RPSGSFKTPN WPDRDYPAGV
TCVWHIVAPK NQLIELKFEK FDVERDNYCR YDYVAVFNGG EINDAERIGK YCGDSPPAPI
VSERNELLIQ FLSDLSLTAD GFIGHYKFRP KKLPTTTALP VTTTFPVSTT SLKPTVALCQ
QKCRRSGTLE SNYCSSNFVL AGTVITTIPR GGSLHATVSI INIYKEGNLA IQQAGKNMSA
KVLVVCKQCP LLRRGLNYII MGQVGEDGRG KIMPNSFIMM FKTKNQKLLD ALKNKQC
//
