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Database: UniProt
Entry: L8LSG4_9CHRO
LinkDB: L8LSG4_9CHRO
Original site: L8LSG4_9CHRO 
ID   L8LSG4_9CHRO            Unreviewed;       268 AA.
AC   L8LSG4;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   SubName: Full=Phosphomethylpyrimidine kinase {ECO:0000313|EMBL:ELR98956.1};
GN   ORFNames=GLO73106DRAFT_00027990 {ECO:0000313|EMBL:ELR98956.1};
OS   Gloeocapsa sp. PCC 73106.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC   Chroococcales; Chroococcaceae; Gloeocapsa.
OX   NCBI_TaxID=102232 {ECO:0000313|EMBL:ELR98956.1, ECO:0000313|Proteomes:UP000011180};
RN   [1] {ECO:0000313|EMBL:ELR98956.1, ECO:0000313|Proteomes:UP000011180}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 73106 {ECO:0000313|EMBL:ELR98956.1,
RC   ECO:0000313|Proteomes:UP000011180};
RX   PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA   Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA   Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA   Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA   Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT   "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT   genome sequencing.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-
CC         amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP;
CC         Xref=Rhea:RHEA:19893, ChEBI:CHEBI:30616, ChEBI:CHEBI:57841,
CC         ChEBI:CHEBI:58354, ChEBI:CHEBI:456216; EC=2.7.4.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00000565};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-
CC         methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+);
CC         Xref=Rhea:RHEA:23096, ChEBI:CHEBI:15378, ChEBI:CHEBI:16892,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58354, ChEBI:CHEBI:456216;
CC         EC=2.7.1.49; Evidence={ECO:0000256|ARBA:ARBA00000151};
CC   -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004948}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ELR98956.1}.
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DR   EMBL; ALVY01000162; ELR98956.1; -; Genomic_DNA.
DR   RefSeq; WP_006528234.1; NZ_ALVY01000162.1.
DR   AlphaFoldDB; L8LSG4; -.
DR   STRING; 102232.GLO73106DRAFT_00027990; -.
DR   PATRIC; fig|102232.3.peg.1260; -.
DR   eggNOG; COG0351; Bacteria.
DR   OrthoDB; 9810880at2; -.
DR   Proteomes; UP000011180; Unassembled WGS sequence.
DR   GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR   CDD; cd01169; HMPP_kinase; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR   InterPro; IPR013749; PM/HMP-P_kinase-1.
DR   InterPro; IPR029056; Ribokinase-like.
DR   NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR   PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR   PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR   Pfam; PF08543; Phos_pyr_kin; 1.
DR   SUPFAM; SSF53613; Ribokinase-like; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:ELR98956.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011180};
KW   Transferase {ECO:0000313|EMBL:ELR98956.1}.
FT   DOMAIN          14..258
FT                   /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT                   /evidence="ECO:0000259|Pfam:PF08543"
SQ   SEQUENCE   268 AA;  28584 MW;  EFCD038DFB48147E CRC64;
     MNDYPVALTI AGSDSGGGAG IQADLRTFAF HRVHGASAIT CITAQNTLGV TAVEGVRPSL
     VGLQITSVAR DLKPKAVKLG MLYNQEIMQT VISQVREWNF SALVVDPVMV SRTGAKLIDE
     AAITTLAREI IPLALIVTPN RYEAQILSGL EIQTWADMEK AAEKIYNLGA KAVLVKGGAM
     AGELQGVDLW FDGQTFYTLK TTRVLTKHNH GTGCTLSAAI AANLALGKTI FQSVVQAKEY
     LTEALKHSLK VGQGHGPVGH FFPLDVVT
//
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