ID L8TS86_9MICC Unreviewed; 844 AA.
AC L8TS86;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=RND superfamily drug exporter {ECO:0000313|EMBL:ELT46198.1};
GN ORFNames=G205_00575 {ECO:0000313|EMBL:ELT46198.1};
OS Arthrobacter nitrophenolicus.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=683150 {ECO:0000313|EMBL:ELT46198.1, ECO:0000313|Proteomes:UP000011189};
RN [1] {ECO:0000313|Proteomes:UP000011189}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SJCon {ECO:0000313|Proteomes:UP000011189};
RX PubMed=23516196; DOI=10.1128/genomeA.00058-13;
RA Vikram S., Kumar S., Vaidya B., Pinnaka A.K., Raghava G.P.;
RT "Draft Genome Sequence of the 2-Chloro-4-Nitrophenol-Degrading Bacterium
RT Arthrobacter sp. Strain SJCon.";
RL Genome Announc. 1:e0005813-e0005813(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELT46198.1}.
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DR EMBL; AOFD01000001; ELT46198.1; -; Genomic_DNA.
DR RefSeq; WP_009356288.1; NZ_AOFD01000001.1.
DR AlphaFoldDB; L8TS86; -.
DR PATRIC; fig|683150.5.peg.116; -.
DR Proteomes; UP000011189; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011189};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 271..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 745..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 294..426
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 443..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 87886 MW; CB1105B1495A1896 CRC64;
MALFLYRLGK FSYRRRWLVI ALWLAALVAV GGSAAAFHGT LSNNFQIPGT ETQRIADKLK
EDLPSASGGS ATIVFEAPEG GFTDEGRAAV TGVLQKLETL PDVRGTVDPF ATQAQVDQAG
QAISDGEQQL AAGQAQLDAS RATLEAGKAQ LAAAEQQLAA AGAPAALVEA QLGQQKAELA
AGEARLQAGQ QELDANKAKL ELGKRQAEAS SAIRFVSGDG RAAVAQVQFN TSINGLSPET
RQQVQDIAHE TSSAGVTALA SKEITEDISE LFGAAEIIGI AVAALVLIIM LGTLVAAGLP
LLMAVVGVGV GVGTTFALSG LFDMSSISPM LALMLGLAVG IDYSLFIVNR HRTQLLAGMD
PEESVARATG TSGNAVVFAG LTVIIALAAL VVPGLPFLTV MGLAAAGTVA VAVLVAITLT
PAMLSLIGRR IISRRAWAQA EAHNAEPGHE AADEAADRER STHGWGGMVT RHPVLALLAG
VLLLGTLALP AAQLQLALPD GGSEPLESEA YQAYDLTARS FGEGVTGPIV AVGEFPANLD
EARAQALQYD VADKLREVEN VVAAVPVALS EDRRTAVFQV IPEEGPASAS TVKVVSELRG
LNDEIQAEYD VAMGLTGQTA GNIDVSTKLG EALPPYLAIV VGLSLILLLL VFRSIVVPLL
ATGGFLLSLA AAFGAVVAVY QWGWLGSVFD VANPGAVLSF LPIILIGVLF GLAMDYQVFI
ASGMREAYMH GSSAKEAVRV GFRHAAAVVT AAAIIMVSVF AGFIFSHLTM VRPLGFAMAF
GVLLDAFVVR MTIVPAVMYL LGEKSWWLPR WLDRILPDVD VEGAKLVKPG SGHPKHAKAA
EPVH
//
