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Database: UniProt
Entry: L8XZP2_TUPCH
LinkDB: L8XZP2_TUPCH
Original site: L8XZP2_TUPCH 
ID   L8XZP2_TUPCH            Unreviewed;       817 AA.
AC   L8XZP2;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   16-MAR-2016, entry version 9.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=TREES_T100012702 {ECO:0000313|EMBL:ELV09493.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV09493.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KB370292; ELV09493.1; -; Genomic_DNA.
DR   InParanoid; L8XZP2; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    389    414       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    435    452       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    530    549       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    561    581       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    588    607       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    627    647       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    753    778       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      253    277       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   817 AA;  91148 MW;  4CBB2828D663ED8A CRC64;
     MGSMFRSEEV ALVQLFLPTA AAYSCVSQLG ELGIVEFRDL NASVSAFQRR FVVDVRRCEE
     LEKTFTFLQE EVRRAGQELP PPEGRLLAPP PRDLLRIQEE TDRLAQELRD VRGNQQALRA
     QLHQLQLHSA VLAQGHGTPL VATHTDGLSE TTPLLQHSKG PHQDLRVNFV AGAVEPHKAA
     ALERLLWRAC RGFLIASFRE VEQQLEDPVT GEPTTWMTFL ISYWGEQIGQ KIRKITDCFH
     CHVFPFLEQE EARQGALQQL KQQSQELQEV LGETERFLGQ VLGRVQVRKM KAVYLALNQC
     SVSTTHKCLI AEAWCATSDL PTLQQALQDS SGEAGVSAVA HRIPCRDMPP TLIRTNRFTA
     SFQGIVDAYG VGRYQEVNPA PYTIITFPFL FAVMFGDVGH GLLMFLFALA MVLAENQPAV
     KSAQNEIWQT FFGGRYLLLL MGLFSIYTGF IYNECFSRAT TIFPSGWSVA AMANQSGWSD
     AFLAQHPVLT LDPNVTGVFL GPYPFGIDPV WSLAINHLSF LNSFKMKMSV ILGVTHMAFG
     VVLGVFNHVH FGQRHRLLLE TLPELIFLLG LFGYLVFLVI YKWLRVSAAS AASAPSILIH
     FINMFLFSQS PTNRPLYHGQ EIVQPTLVVL ALAMVPVLLL GTPLYLLRHS RRRPRKNDET
     DKARLLDSPD VSVNGWGSDE EMAGCPGDEK DAEFVPSEVF MHQAIHTIEF CLGCISNTAS
     YLRLWALSLA HAQLSEVLWA MVMRVGLGMG RELGVAAVVL VPVFAAFAVL TVAILLVMEG
     LSAFLHALRL HWVEFQNKFY AGTGYKLSPF TFALEDE
//
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