ID L8Y4T2_TUPCH Unreviewed; 779 AA.
AC L8Y4T2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 03-MAY-2023, entry version 34.
DE SubName: Full=NACHT, LRR and PYD domains-containing protein 9 {ECO:0000313|EMBL:ELV11453.1};
GN ORFNames=TREES_T100017429 {ECO:0000313|EMBL:ELV11453.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV11453.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB365142; ELV11453.1; -; Genomic_DNA.
DR AlphaFoldDB; L8Y4T2; -.
DR InParanoid; L8Y4T2; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF13; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 9; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 5.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 103..301
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 779 AA; 86876 MW; D80B7AF6CB6191AC CRC64;
MPWTELKKAS KGDLAQLLEK HYPAEQAWAV TLSLFLQLGR RDLWTKAQDE IRNRLNPYRK
HVKEKFRLVW EKEIRLQVPE HFYRETTRSA REALADAFAA GPATVVLRGP EGSGKTTLLR
KVMLEWAEGN FWKDRFTFVF FLNVCEMSCR AETSLVELIS KDWPEAPAAM EDTFSQPERI
LFVMDSFEAL KWDLALKGHS CSDWRQRRPA QVILGSLLQK QLLAESCLLL ALGKGGVQKY
GLLLRDPQHI LLSGFSERER KSYFSHFFCE KNKALKAFGF ARDTRPLLTL CQNPLVCWLV
CTCIKCQLET GPDLSISSQN MSALYVSFLT SVLKAGAESR PPRQSRARLT SLCALAAELR
RKGMSNSDVS LWVAARLLQR SGEHFIFKHV CIQEFCAAVF YLLQRPRDSP HLAIGSVTQL
VTAWVANVQT HLSRLGVFVF GISTEEVIGQ LETSFGFLLS RDIKQEITAC VQSLSHCKTD
QEVVSFNELF NGLFETQDEE FVAHVMNFFE EVSTYIGDVG QLLVSSYCLK LCQNLKKLHL
CIDDVFSDDS GSVADDSEKL LYWQDLCSVF RTCKGLEMLD LDNCSLDGAS TAVLREALAR
PDCKLQSLLL NFMSSFGSGA DFFEVVLHSP HLRHLNLCGT SLSRAGLRLL CETLKHPTCS
VRELLLGKCD ITEEGCDDLA PVLACSDRLK HLSLAENPVK DQGVTVLCGA LERPGCALQS
LVLSGCGLTA ASCAHISRAL LCAQSLSLLD LSLNCLEGGG ALTLCAALTH PACSLQELW
//
