ID L8Y4Z3_TUPCH Unreviewed; 970 AA.
AC L8Y4Z3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Receptor-type tyrosine-protein phosphatase O {ECO:0000313|EMBL:ELV10119.1};
GN ORFNames=TREES_T100003658 {ECO:0000313|EMBL:ELV10119.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV10119.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB368666; ELV10119.1; -; Genomic_DNA.
DR AlphaFoldDB; L8Y4Z3; -.
DR STRING; 246437.L8Y4Z3; -.
DR InParanoid; L8Y4Z3; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR042996; PTPRO.
DR PANTHER; PTHR47028; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O; 1.
DR PANTHER; PTHR47028:SF1; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00194; PTPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022912};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:ELV10119.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 698..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 401..497
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 589..679
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 776..970
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
SQ SEQUENCE 970 AA; 109144 MW; 9A9F8B6183896C2F CRC64;
MLQALGRFLP PEQGPDRILH SPSISCSCLG SVTLCIRLGR LRWGQTAATF HVTVQDDNSI
VVSLEASDVI SPASVYVVKI TGESKNYFFE FEEFNSTLPP PVIFQASYHG LYYIITLVVV
NGNVVTKPSR SVTVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF TRVNISYWEG
KDFRTLLYTD FFKGKTVFNH WLPGICYSNI TFQLVSEATF NKSTLVEYSG VSHEPKQHRT
APYPPRNISV RIVNLNKNNW EEQSGSFPEE PFMRSQDTTG KDKLFHFTDE TPELPSGNTS
SGWPDFNSSD FETTSQPYWW DSASATPESE DEFVSVLPME YENNNTLSET EKSTSGSFSF
FPVQMILSWL PPKPPTAFDG FHIHIEREGP SGEWIEELTE KPQHVSVHVL SSTSALMSWT
SSQENYNSTI VSVVSLTCQK QKESQRLEKQ YCTQVNSSKP VIENLVPGAQ YQVVMYLRKG
PLIGPPSDPV TFAIAPVAPE ITSVEYINSL LYISWKYGDD TTDLSHSRML HWMVVAEGKK
KIKKSVTRNV MTAILSLPPG DIYNLSVTAC TERGSNTSML RLIKLEPAPP KSLFAVNKTQ
TSVTLLWVEE GVADFFEVFC QQVGSRQETK LQEPVAVSSH VVTISSLLPA TAYNCSVTSF
SHDSPSIPTF IAVSTMANEN CDENVWPISS VTEMNPNVVV ISVLAILSTL LIGLLLVTLV
ILRKKHLQMA RECGAGTFVN FASLERDGKL PYNCPVQLDD FDAYIKDMAK DSDYKFSLQF
EELKLIGLDI PHFAADLPLN RCKNRYTNIL PYDFSRVRLV SMNEEEGADY INANYIPGYN
SPQEYIATQG PLPETRNDFW KMVLQQKSQI IVMLTQCNEK RRVKCDHYWP FTEEPIAYGD
ITVEMISEEE QDDWACRHFR INYVSHYQEP GCCPPITATT TTPLMPCQCG GTNLLPCKMM
NLPGSAMLFI
//
