ID L8Y5F5_TUPCH Unreviewed; 927 AA.
AC L8Y5F5;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=PERQ amino acid-rich with GYF domain-containing protein 2 {ECO:0000313|EMBL:ELV09596.1};
GN ORFNames=TREES_T100019100 {ECO:0000313|EMBL:ELV09596.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV09596.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SIMILARITY: Belongs to the GIGYF family.
CC {ECO:0000256|ARBA:ARBA00038015}.
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DR EMBL; KB370174; ELV09596.1; -; Genomic_DNA.
DR AlphaFoldDB; L8Y5F5; -.
DR STRING; 246437.L8Y5F5; -.
DR eggNOG; KOG1862; Eukaryota.
DR InParanoid; L8Y5F5; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051216; P:cartilage development; IEA:InterPro.
DR Gene3D; 3.30.1490.40; -; 1.
DR InterPro; IPR003169; GYF.
DR InterPro; IPR035445; GYF-like_dom_sf.
DR InterPro; IPR031500; SNORC.
DR PANTHER; PTHR14445; GRB10 INTERACTING GYF PROTEIN; 1.
DR PANTHER; PTHR14445:SF38; GRB10-INTERACTING GYF PROTEIN 2; 1.
DR Pfam; PF15756; DUF4690; 1.
DR Pfam; PF02213; GYF; 1.
DR SMART; SM00444; GYF; 1.
DR SUPFAM; SSF55277; GYF domain; 1.
DR PROSITE; PS50829; GYF; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 652..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 894..921
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 133..181
FT /note="GYF"
FT /evidence="ECO:0000259|PROSITE:PS50829"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 927 AA; 108021 MW; 426D179F096E5E1F CRC64;
MAAETQTLNF GPEWGDRRFE KPGRKDVGWR EHMERRRRFE FDFRDRDDER GYRRVRSGSG
SIDDDRDSLP EWCLEDAEEE MGTFDSSGAF LSLKKVQKEP IPEEQEMDFR PVEEGEECSD
SEGSHNEEAK EPDKTNKKEG EKADRVGPFN NQEMAEWFQA GYFTMSLLVK RACDESFQPL
GDIMKMWGRV PFSPGPAPPP HMGELDQERL TRQQELTALY QMQHLQYQQF LLQQQYAQVL
AQQQKAALSS QQQQQLALLL QQFQALKMRI SDQNIIPSVT RSVSVPDTGS IWELQSATSQ
PTVWEGGSVW DLPLDPATPG PALEQLQQLE KAKAAKLEQE RREAEMRAKR EEEERKRQEE
LRRQQEEILR RQQEEERKRR EEEELARRKQ EEALRRQREQ EIALRRQREE EERQQQEEAL
RRLEERRREE EERRKQEELL RKQEEALRRQ REQEIALRRQ REEEERQQQE EALRRLEERR
REEEERRKQE ELLRKQEEEA AKWAREEEEA QRRLEENRLR MEEEAARLRH EEEERKRKEL
ELQRQKELMR QRQAPPERLP RQRRQQRELM KALQQQQQQQ QQQKLTGWGN VSKPAGTTKS
LLEIQQEEAR QMQKQQQQQQ QQQQQQPNRA RSNTVRSFAH AAAVRLVSPS FLTLWALLLM
LSAMIIFLFL QQHSNLHTSI GTSVWGSINT GPPNQWASDL VSSIWSNADT KNSNMGFWDD
AVKEVGPRNS SNKNKNNASL SKSVGVSNRQ NKKVEEEEKL LKLFQGVNKA QDGFTQWCEQ
MLHALNTANN LDVPTFVSFL KEVESPYEVH DYIKAYLGDT SEAKEFAKQF LEPEGPGPEP
TLWSEPAELP SGEGPFESTS PQEPAATGPP APTAPPGPED STVRERLDQG NGSLGPGAIA
AIVIAALLAT CVVLALVVVA LRKFSAS
//
