ID L8Y864_TUPCH Unreviewed; 455 AA.
AC L8Y864;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Ribonuclease inhibitor {ECO:0000256|ARBA:ARBA00014554};
DE AltName: Full=Ribonuclease/angiogenin inhibitor 1 {ECO:0000256|ARBA:ARBA00032534};
GN ORFNames=TREES_T100004720 {ECO:0000313|EMBL:ELV12618.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV12618.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG.
CC May play a role in redox homeostasis. {ECO:0000256|ARBA:ARBA00025561}.
CC -!- SUBUNIT: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
CC {ECO:0000256|ARBA:ARBA00011699}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB364419; ELV12618.1; -; Genomic_DNA.
DR RefSeq; XP_006164515.1; XM_006164453.2.
DR RefSeq; XP_006164516.1; XM_006164454.2.
DR RefSeq; XP_006164517.1; XM_006164455.2.
DR RefSeq; XP_014437986.1; XM_014582500.1.
DR AlphaFoldDB; L8Y864; -.
DR STRING; 246437.L8Y864; -.
DR GeneID; 102495153; -.
DR KEGG; tup:102495153; -.
DR CTD; 6050; -.
DR eggNOG; KOG4308; Eukaryota.
DR InParanoid; L8Y864; -.
DR OrthoDB; 55870at2759; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR041302; LRR_RI_cap.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF13516; LRR_6; 8.
DR Pfam; PF18779; LRR_RI_capping; 1.
DR SMART; SM00367; LRR_CC; 6.
DR SMART; SM00368; LRR_RI; 14.
DR SUPFAM; SSF52047; RNI-like; 2.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
SQ SEQUENCE 455 AA; 49256 MW; BFD0CF2489B62212 CRC64;
MSLDIQCEHL SDTRWTELLP LIQQYSVVRL DDCGLTEAHC KDICPALQAN SGLTELSLRT
NELGDAGVHL VLQGLQSPTC KVQKLSLQNC CLTEAGCAVL PAALRRMPTL RELHLNDNPL
GDAGLRLLCE GLLDPQCHLE KLQLEYCNLT AASCEALAAV LWAKPGFKEL MVSNNGIGEA
GVRVLCQGLR DSACQLETLK LENCGVTPAN CKDLCGIVAE ASLQEVDLGS NDLGDAGIAE
LCPGLLRPSS RVKTLWLWEC GITAEGCRHL CQVLRAKGSL KELSLAGNEL GDEGARLLCE
SLLDPACQLQ SLWVKSCCLT ATCCPHFSSV LAQNKSLQEL QISSNKLGDA GVQQLCQGLS
QPSSTLRVLW LGDCEVSDDG CSTLASVLLA SRSLRELDLS NNCMGDLGIQ QLIESLRQPG
CALEQLVLYD IYWTEEMDRQ LKILEGQKPS LRIIS
//
