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Database: UniProt
Entry: L8YD86_TUPCH
LinkDB: L8YD86_TUPCH
Original site: L8YD86_TUPCH 
ID   L8YD86_TUPCH            Unreviewed;       530 AA.
AC   L8YD86;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE            EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN   ORFNames=TREES_T100005777 {ECO:0000313|EMBL:ELV13014.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV13014.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC         Evidence={ECO:0000256|RuleBase:RU362059};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059}; Single-
CC       pass membrane protein {ECO:0000256|RuleBase:RU362059}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR   EMBL; KB363445; ELV13014.1; -; Genomic_DNA.
DR   RefSeq; XP_006163643.1; XM_006163581.2.
DR   AlphaFoldDB; L8YD86; -.
DR   STRING; 246437.L8YD86; -.
DR   GeneID; 102501792; -.
DR   KEGG; tup:102501792; -.
DR   eggNOG; KOG1192; Eukaryota.
DR   InParanoid; L8YD86; -.
DR   OrthoDB; 382054at2759; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR48043:SF12; UDP-GLUCURONOSYLTRANSFERASE 2B17-RELATED; 1.
DR   Pfam; PF00201; UDPGT; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU003718};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Signal {ECO:0000256|RuleBase:RU362059};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW   Transmembrane {ECO:0000256|RuleBase:RU362059};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362059}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT   CHAIN           24..530
FT                   /note="UDP-glucuronosyltransferase"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT                   /id="PRO_5005139386"
FT   TRANSMEM        494..517
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
SQ   SEQUENCE   530 AA;  60719 MW;  F9373DB71119523C CRC64;
     MSKVWTSFLL LIQLCCYFSC GSCGKVLVWP MEYSHWINLK TILDELAQRG HEVTVLTSSA
     SILVDPSKPS AINFEVYPTS LTKAEFDFRF MKWIKIWVYE LSGSTLWAYN SKMQSIYYEY
     SDTALELCQD AILNKKLIKK LKESRFDVVV GDVISPCGEL LSELLNLPLV YSLRFTTGKT
     LEKFCGGLLL PPSYVPVVLS ELSDKMTFME RVTNMFYYLF FDYAFETFNT KKWDQFYSEV
     LGRPTTLCEI MGKADIWLIR TYWDFEFPHP YLPNFEFVGG LQCKPAKPLP KEIEEFVQSS
     GEDGIVVFSL GSMVKNLTDE KANIVASALA QIPQKVLWRY EGNKPAALGA NTRLYDWIPQ
     NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPMFADQ PDNIAHMKAK GAAVDVNMDT
     MTSSDLLNAL KTVINEPFYK ENAMRLSRIH HDQPVKPLDR AVFWIEFVMR HKGAKHLRVA
     AHDLTWFQYH SLDVIGFLLA CILSAMFLIT KCCLFSYRKI CKTRKKKKRE
//
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