ID L8YDC9_TUPCH Unreviewed; 530 AA.
AC L8YDC9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 6 {ECO:0000313|EMBL:ELV12970.1};
GN ORFNames=TREES_T100008143 {ECO:0000313|EMBL:ELV12970.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV12970.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB363509; ELV12970.1; -; Genomic_DNA.
DR AlphaFoldDB; L8YDC9; -.
DR STRING; 246437.L8YDC9; -.
DR eggNOG; KOG1385; Eukaryota.
DR InParanoid; L8YDC9; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF99; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 6; 1.
DR Pfam; PF01150; GDA1_CD39; 2.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833, ECO:0000313|EMBL:ELV12970.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 196
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 226..230
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 530 AA; 57360 MW; AD656558E05F717E CRC64;
MRKRPNHGSL RMAKVAYPLG LCVGLFIYIA YIKWHRASAT QAFFSIASAA SAARWSQQAH
SPPGTAARGH EVFYGIMFDA GSTGTRVHIF HFARPPGETP TLTHETFKAL KPGLSAYADD
VEKSSQGIQE LLDVAKQDIP FDFWKATPLV LKATAGLRLL PGEKAQKLLQ KVEEVFKASP
FLVGDDCVSI MNGTDEGVSA WITVNFLTGS LKTPGRSSVG VLDLGGGSTQ ITFLPRVEGT
LQTSPPGYLT ALQVFNRTYR LYSYRSGATL TQMLLHSYLG LGLMSARLAI LGGVEGKPAK
DGKELVSPCL PPGFKGEWEH AEVTYRLSGT TAEASLHALC ASRVSEVLRD RVHRTEDVKH
VDFYAFSYYY DLAAHVGLIG PYQHGEHLPT TVTTVSEDGG PWKPGICNSQ CPGALSGPSP
AMGLSGSVCH ASADGRAISP PDAEKGGSLT VGDFEIAAKY VCRTLETQPR HGPFTCMDLT
YISTLLQEFG FPRTTELKLT RKIDNVETSW ALGAIFHYID SLSRQKSPAS
//