ID L8YDP3_TUPCH Unreviewed; 760 AA.
AC L8YDP3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Rho guanine nucleotide exchange factor 10 {ECO:0000313|EMBL:ELV13214.1};
GN ORFNames=TREES_T100021129 {ECO:0000313|EMBL:ELV13214.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV13214.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB362325; ELV13214.1; -; Genomic_DNA.
DR AlphaFoldDB; L8YDP3; -.
DR STRING; 246437.L8YDP3; -.
DR InParanoid; L8YDP3; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 380..535
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 85476 MW; F45718E8A683E9AB CRC64;
MDQRELPPPT PEAAENEVKY DTNNNEEEEG EQFDFDSGDD IPEADRQAPS TLEASSAEAR
EAAPTAGDEN GSGTEATAVV EPTKLVVPLK VNPYSVIDIT PFQEDQPPTP DPNPEEEGGG
LHVPSGYSVP VPCGYAVPSN LPLLLPAYSS PVIIRTVSVD EGETPEVTEE HQFNSLSSEE
PPNSEDQVSK EDSALARWVA DPANTAWMDN PEEAIYDDVP RENSDSEPDE MIYDDVENGD
EGGNSSLEYG WSSSEFESYE EQSDSECKNG VPRSFLRSSH KRQARMQSAC LSHDLTRLKE
HYEKKMRELM ASTVGAVELQ QLKQRHEVKM QKLMKAAREG TKDGLEKTKA AVKRGRSFIR
TKSFISQDHR SCLDEEQNVF IDVECRHPEA ILTPMPEGLS QQQQYEKPLS EMEPKILSER
KLKMVFYRIK EILQCHSMFQ IALASRVSEW DAVEMIGDVF VASFSKSMVL DAYSEYVNNF
STAVAVLKKT CATKPAFLEF LKQCQESSPD RTTLYSLMMK PIQRFPQFIL LLQLLSSGNR
YLIRSDDMIE TVYNDRGEIM KTKERRLFML NDVLMCATVS SRSGRPTFFT AVFNTFTPAI
KESWINNLQM AKLALEEENH MGWFCVEDDG NQIKKEKHPL LVGHMPVLVA KQQEFKIECA
AYNPEPYLNN ESQPDSFSTA HGFLWIGSCT NQMGQIAIVS FQNSNPKVIE CFNVESRILC
MVYVPVKEKP REPDAVSDPE PTATRASDIP TICLGMEEGR
//
