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Database: UniProt
Entry: L8YHG1_TUPCH
LinkDB: L8YHG1_TUPCH
Original site: L8YHG1_TUPCH 
ID   L8YHG1_TUPCH            Unreviewed;      4763 AA.
AC   L8YHG1;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   25-OCT-2017, entry version 29.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|EMBL:ELV13961.1};
GN   ORFNames=TREES_T100006874 {ECO:0000313|EMBL:ELV13961.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELV13961.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB359748; ELV13961.1; -; Genomic_DNA.
DR   ProteinModelPortal; L8YHG1; -.
DR   InParanoid; L8YHG1; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:ELV13961.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4286   4306       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4563   4585       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4644   4667       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      211    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      584    800       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1016   1211       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1360   1573       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1874   1924       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4763 AA;  537775 MW;  25D295C60CACA0E8 CRC64;
     MGDGGEGEDE VQFLRTDDEV VLQCSATVLK EQLKLCLAAE GFGNRLCFLE PTSNAQNVPP
     DLAICCFVLE QSLSVRALQE MLANTVEAGV ESSQGGGHRT LLYGHAILLR HAHSRMYLSC
     LTTSRSMTDK LAFDVGLQED ATGEACWWTM HPASKQRSEG EKVRVGDDII LVSVSSERYL
     HLSTASGELQ VDASFMQTLW NMNPICSGCE EGSVTGGHVL RLFHGHMDEC LTISPADSED
     QRRLVFYEGG AVCTHARSLW RLEPLRISWS GSHLRWGQPL RIRHVTTGRY LALTEDQGLV
     VIDASKAHTK ATSFCFRISK EKLDVAPKRD VEGMGPPEIK YGESLCFVQH VASGLWLTYA
     APDTKALRLG VLKKKAMLHQ EGHMDDALSL TRCQQEESQA ARMIHSTSGL YNQFINAAHR
     GCYPEPAGPQ RLLRATLRPI EGVILSLQDL IGYFEPPSEE LQHEEKQSKL RSLRNRQSLF
     QEEGMLSLVL NCIDRLNVYT TAAHFAEFAG EEAAESWKEI VNLLYELLAS LIRGNRTNCA
     LFSTNLDWLV SKLDRLEASS GILEVLYCVL IESPEVLNII QENHIKSIIS LLDKHGRNHK
     VLDVLCSLCV CNGVAVRSNQ DLITENLLPG RELLLQTNLI NYVTSIRPNI FVGRAEGSTQ
     YGKWYFEVMV DEVVPFLTAQ ATHLRVGWAL TEGYSPYPGG GEGWGGNGVG DDLYSYGFDG
     LHLWTGHVAR PVTSPGQHLL APEDVVSCCL DLSVPSISFR INGCPVQGVF EAFNLDGLFF
     PVVSFSAGVK VRFLLGGRHG EFKFLPPPGY APCHEAVLPR ERLHLEPIKE YRREGPRGPH
     LVGPSRCLSH TDFVPCPVDT VQIVLPPHLE RIREKLAENI HELWALTRIE QGWTYGPVRD
     DNRRLHPCLV DFHSLPEPER NYNLQMSGET LKTLLALGCH VGMADEKAED NLKKTKLPKT
     YMMSNGYKPA PLDLSHVRLT PAQTTLVDRL AENGHNVWAR DRVAQGWSYS AVQDIPARRN
     PRLVPYRLLD EATKRSNRDS LCQAVRTLLG YGYNIEPPDQ EPSQVENQSR WDRVRIFRAE
     KSYAVQSGRW YFEFEAVTTG EMRVGWARPE LRPDVELGAD ELAYVFNGHR GQRWHLGSEP
     FGRPWQSGDV VGCMIDLTEN TIIFTLNGEV LMSDSGSETA FRDIEIGDGF LPVCSLGPGQ
     VGHLNLGQDV SSLRFFAICG LQEGFEPFAI NMQRPVTTWF SKSLPQFEAV PLEHPHYEVA
     RMDGTVDTPP CLRLSHRTWG SQNSLVEMLF LRLSLPVQFH QHFRCTAGAT PLAPPGQQPP
     AEDEARAAEP DPDYENMRRS AGGWGEAESG KEGTAKEGVA GGAPQAGVEA QPVRAENEKD
     ATTEKNKKRG FLFKAKKVAM MTQPPATPTL PRLPRDVVPA DDRDDPEIIL NTTTYYYSVR
     VFAGQEPSCV WVGWVTPDYH QHDMSFDLSK VRAVTVTMGD EQGNVHSSLK CSNCYMVWGG
     DFVSPGQQGR ISHTDLVIGC LVDLATGLMT FTANGKESNT FFQVEPNTKL FPAVFVLPTH
     QNVIQFELGK QKNIMPLSAA MFLSERKNPA PQCPPRLEVQ MLMPVSWSRM PNHFLQVETR
     RAGERLGWAV QCQEPLTMMA LHIPEENRCM DVLELSERLD LQRFHSHTLR LYRAVCALGN
     NRVAHALCSH VDQAQLLHAL EDAHLPGPLR AGYYDLLISI HLESACRSRR SMLSEYIVPL
     TPETRAITLF PTERSTENGP RHHGLPGVGV TTSLRPPHHF SPPCFVTALP AAGVTEAPVR
     LSPAIPLEAL RDKALRMLGE AVRDGGQHAR DPVGGSVEFQ FVPVLKLVST LLVMGVFGDE
     DVKQILKMIE PEVFTEEEEE DEEEEEEGEE EDEEEKEEDE EEEAQEKEDE EKEEEEAAEG
     DKEEGLEEGL LQMKLPESVK LQMCHLLEYF CDQELQHRVE SLAAFAERYV DKLQGNQRGR
     YGLLMKAFTM SAAETARRTR EFRSPPQEQI NMLLHFKDGT DEEDCPLPEE IRQDLLDFHQ
     DLLAHCGIQL DGEEEEPEEE TTLGSRLMSL LEKVKLVKKE EEKPEEEPPA EESKPQSLQE
     LVSHTVVRWA QEDFVQSPEL VRAMFSLLHR QYDGLGELLR ALPRAYTISP SSVDDTMSLL
     ECLGQIRSLL IVQMGPQEEN LMIQSIGNIM NNKVFYQHPN LMRALGMHET VMEVMVNVLG
     GGESKEIRFP KMVTSCCRFL CYFCRISRQN QRSMFDHLSY LLENSGIGLG MQGSTPLDVA
     AASVIDNNEL ALALQEQDLE KVVSYLAGCG LQSCPMLLAK GYPDIGWNPC GGERYLDFLR
     FAVFVNGESV EENANVVVRL LIRKPECFGP ALRGEGGSGL LAAIEEAIRI SEDPARDGPG
     VRRDRRREHF GEEPPEENRV HLGHAIMSFY AALIDLLGRC APEMHLIQAG KGEALRIRAI
     LRSLVPLDDL VGIISLPLQI PTLGKDGALV QPKMSASFVP DHKASMVLFL DRVYGIENQD
     FLLHVLDVGF LPDMRAAASL DTHHGDGAGT DYLCLAVLPL ITKCAPLFAG TEHRAIMVDS
     MLHTVYRLSR GRSLTKAQRD VIEDCLMALC RYIRPSMLQH LLRRLVFDVP ILNEFAKMPL
     KLLTNHYERC WKYYCLPTGW ANFGVTSEEE LHLTRKLFWG IFDSLAHKKY DQELYRMAMP
     CLCAIAGALP PDYVDASYSS KAEKKATVDA EGNFDPRPVE TLNVIIPEKL DSFINKFAEY
     THEKWAFDKI QNNWSYGENI DEELKTHPML RPYKTFSEKD KEIYRWPIKE SLKAMIAWEW
     TIEKAREGEE EKTEKKKTRK ISQTAQTYDP REGYNPQPPD LSGVTLSREL QAMAEQLAEN
     YHNTWGRKKK QELEAKGGGT HPLLVPYDTL TAKEKARDRE KAQELLKFLQ MNGYAVTRQG
     LKDMELDTSS IEKRFAFGFL QQLLRWMDIS QEFIAHLEAV VSSGRVEKSP HEQEIKFFAK
     ILLPLIKQYF TNHCLYFLST PAKVLGSGGH ASNKEKEMIT SLFCKLAALV RHRVSLFGTD
     APAVVNCLHI LARSLDARTV MKSGPEIVKA GLRSFFESAS EDIEKMVENL RLGKVSQART
     QVKGVGQNLT YTTVALLPVL TTLFQHIAQH QFGDDVILDD VQVSCYRTLC SIYSLGTTKN
     AYVEKLRPAL GECLARLAAA MPVAFLEPQL NEYNACSVYT TKSPRERAIL GLPNSVEEMC
     PDIPVLERLM ADIGGLAESG ARYTEMPHVI EITLPMLCSY LPRWWERGPE APPPALPAGA
     PPPCTAVTSD HLNSLLGNIL RIIVNNLGID EASWMKRLAV FAQPIVSRAR PELLRSHFIP
     TIGRLRKRAG KVVAEEEQLR LEAKAEAEEG ELLVRDEFSV LCRDLYALYP LLIRYVDNNR
     AHWLTEPNPS AEELFRMVGE IFIYWSKSHN FKREEQNFVV QNEINNMSFL TADNKSKMAK
     SGGSDQERTK KQRRGDRYSV QTSLIVATLK KMLPIGLNMC APTDQDLITL AKTRYALVEG
     SPSLRWQMAL YRGVPGREED ADDPEKIVRR VQEVSAVLYH LDQIEHPYKS KKAVWHKLLS
     KQRRRAVVAC FRMTPLYNLP THRACNMFLE SYKASWILTE DHSFEDRMID DLSKAGEQEE
     EEEEVEEKKP DPLHQLVLHF SRTALTEKSK LDEDYLYMAY ADIMAKSCHL EEGGENGEGE
     EEEPEVSFEE KEMEKQRLLY QQARLHNRGA AEMVLQMISA CKGETGAMVS STLKLGISIL
     NGGNAEVQQK MLDYLKDKKE VGFFQSIQAL MQTCSVLDLN AFERQNKAEG LGMVNEDGTG
     EKVMADDEFT QDLFRFLQLL CEGHNNDFQN YLRTQTGNTT TINIIICTVD YLLRLQESIS
     DFYWYYSGKD VIEEQGKRNF SKAMAVAKQV FNSLTEYIQG PCTGNQQSLA HSRLWDAVVG
     FLHVFAHMMM KLAQDSSQIE LLKELLDLQK DMVVMLLSLL EGNVVNGMIA RQMVDMLVES
     SSNVEMILKF FDMFLKLKDI VGSEAFQDYV TDPRGLISKK DFQKAMDSQK QFTGPEIQFL
     LSCSEADENE MINCEEFANR FQEPARDIGF NVAVLLTNLS EHMPHDPRLR NFLELAESIL
     EYFRPYLGRI EIMGASRRIE RIYFEISETN RAQWEMPQVK ESKRQFIFDV VNEGGEAEKM
     ELFVDGEEEE QPPEPEPEPE PEPEKADAEN GEKEEVPEPP PEPSQKTAPP PPPPKKEEAG
     GAGMEFWGEL EVQRVKFLNY LSRNFYTLRF LALFLAFAIN FILLFYKVSD SPPGEDDMEG
     SAAGDLSGAG SGGGSGWGSG AGEEAEGDED ENMVYYFLEE STGYMEPALR CLSLLHTLVA
     FLCIIGYNCL KVPLVIFKRE KELARKLEFD GLYITEQPED DDVKGQWDRL VLNTPSFPSN
     YWDKFVKRKV LDKHGDIYGR ERIAELLGMD LATLEITAHN ERKPDPPPGL LTWVMSIDVK
     YQIWKFGVIF TDNSFLYLGW YMVMSLLGHY NNFFFAAHLL DIAMGVKTLR TILSSVTHNG
     KQLVMTVGLL AVVVYLYTVV AFNFFRKFYN KSEDEDEPDM KCDDMMTCYL FHMYVGVRAG
     GGIGDEIEDP AGDEYELYRV VFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVKEDM
     ETKCFICGIG SDYFDTTPHG FETHTLEEHN LANYMFFLMY LINKDETEHT GQESYVWKMY
     QERCWDFFPA GDCFRKQYED QLS
//
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