ID L9JGU5_TUPCH Unreviewed; 1443 AA.
AC L9JGU5;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=TREES_T100001957 {ECO:0000313|EMBL:ELW48277.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW48277.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB321066; ELW48277.1; -; Genomic_DNA.
DR STRING; 246437.L9JGU5; -.
DR eggNOG; KOG1240; Eukaryota.
DR InParanoid; L9JGU5; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045324; P:late endosome to vacuole transport; IEA:InterPro.
DR GO; GO:0016236; P:macroautophagy; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13980; STKc_Vps15; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045162; Vps15-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17583; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR PANTHER; PTHR17583:SF0; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ELW48277.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 26..324
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 417..455
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 462..492
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 988..1029
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 836..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1320..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1421..1443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..854
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1423..1437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1443 AA; 161532 MW; 2E2EBB45105331ED CRC64;
MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP
TLPLTSYKQE LEELKIRLHS AQNCLPFQKA AERASEKAAM LFRQYVRDNL YDRISTRPFL
NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP
ADFNYFFDTS RRRTCYIAPE RFVDGGMFAA ESEYMRDPST PLVDLNSNQR TRGELKRAMD
IFSAGCVIAE LFTEGAPLFD LSQLLAYRNG HFSPEQVLNK IEDRSIRELV TQMIHREPDK
RLEAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERVLVIRKDL GNIIHNLCGQ
ELPEKAGEPR ESGLVILVSV ITSCLQTLRY CDSKLAALEL ILHLAPRLSV EILLDRITPY
LLHLSSDSVP RVRAEALRTL TRVLALVKEV PRNDTNIYPE YILPGIAHLA QDSATIVRLA
YAENIALLAE TALRFLELVQ LKNLNMENDP GSEEIDEVPH PNGNYDTELQ ALHEMVQQKV
VTLLSDPENI VKQTLMESGI TRLCVFFGRQ KANDVLLSHM ITFLNDKNDW HLRGAFFDSI
VGVAAYVGWQ SSSILKPLLQ QGLSDAEEFV VVKALSALTC MCQLGLLQRP HVYEFASDIA
PFLCHPNLWI RYGAVGFISV VAGQISTADV YCKLMPYLDP YITQPIIQIE RQLVLLSVLK
EPVSRSIFDY ALRSKDIASL FRHLHLRQKK RRGSLPACPP PEDPVIAQLL KKLLSQGMTE
EEEDKLLALK DFMMKSNKAK ANVVDHSSLH DSSQKGAIDL AAVGITGRQV DLVRTRQEPD
DKRARKHVKQ DSNVNEEWKS MFGSLEPPSV PQALPKGSDQ EVVPTGRPPR SESSAGICAP
PSTSTQVPEV THVQNKKPVV QVLSSTILPS TYQIRITTCK TELQQLIQQK REQCNAERIA
KQMMENAEWE SKPPPPGWHP KGLLVAHLHE HKSAVNRIRV SDEHSLFATC SNDGTVKIWN
SQKMEGKTTT TRSILTYSRL GGRVRTLAFC QGSHYLAVAS DNGAVQLLGI EASKLPKSPK
IHPLQSRTLD PKEDGCVVDM HHFHAGAQSV LAYATVHGSL VGWDLRASSN AWTLKHDLKA
GLITSFAVDI HQCWLCIGTS SGTMACWDMR FQLPISSHYH PSRARVRRLS MHPLHQSWVI
AAVQGNNEVS TWDLETGDRR FTLWASSAPP LSELQGNRCL VSDSVFISLK PSPHSVHGIY
CSPADGNPIL LTAGSDMKIR FWDLAYPERS YIVAGSTSSP SVSYYRKIIE GTEVVQEIQN
KQKVGPSEDT PRRGPESLPV GHHDIITDVA TFQTTQGFIV TASRDGIVKA PTKEGVQWRG
RPGEQEVRAA SARRLQGEPC SSRADSQACF GPDFRKYLLL DSSPDSSLDS SPTKGGRFQA
EAS
//
