ID L9JHS0_TUPCH Unreviewed; 3196 AA.
AC L9JHS0;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=DNA polymerase zeta catalytic subunit {ECO:0000256|ARBA:ARBA00021589};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=TREES_T100016200 {ECO:0000313|EMBL:ELW50116.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW50116.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR EMBL; KB320987; ELW50116.1; -; Genomic_DNA.
DR STRING; 246437.L9JHS0; -.
DR eggNOG; KOG0968; Eukaryota.
DR InParanoid; L9JHS0; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR CDD; cd05778; DNA_polB_zeta_exo; 1.
DR CDD; cd05534; POLBc_zeta; 1.
DR CDD; cd22287; REV3L_RBD; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR032757; DUF4683.
DR InterPro; IPR030559; PolZ_Rev3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR025687; Znf-C4pol.
DR PANTHER; PTHR45812; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45812:SF1; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 2.
DR Pfam; PF15735; DUF4683; 1.
DR Pfam; PF14260; zf-C4pol; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 17..109
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 550..936
FT /note="DUF4683"
FT /evidence="ECO:0000259|Pfam:PF15735"
FT DOMAIN 2345..2550
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 2616..3066
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 3108..3175
FT /note="C4-type zinc-finger of DNA polymerase delta"
FT /evidence="ECO:0000259|Pfam:PF14260"
FT REGION 233..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1644..1668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1761..1781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1865..1947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2027..2050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2133..2215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..863
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1014
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1340..1366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1375..1389
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1865..1898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1912..1937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2027..2049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2133..2166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2180..2205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3196 AA; 359988 MW; 5EF93C7352AA8274 CRC64;
MAFSIDRALN VALGNPSSTA QHVFKVSLVS GMPFYGYHEK ERHFMKIYLY NPAMMKRICE
LLQSGAIMNK FYQPHEAHIP YLLQLFIDYN LYGMNLINLA AVKFRKARRK SGILHATGSR
KDRLSGNSPG TLFRWEEDEI PSSLILEGVE PQSTCELEVD AVAADILNRL DIEGHRHKVE
EAFINEEAIL NLMENSQTFQ PLTQRLSESP VFMASSPDEA LVHLLAGLES DGYQGEKNRM
PSPCHSFRNT KNLQNSDDEE NEPQIEKEEM ELSLVMSQRW DSNIEEHCAK KRSLCRNTHR
SSSEDDDSSS DEEMEWSDNN LLLANLSIPQ LDGTADENSD NPLNNENSRT HSSVIATSKL
SVKPSIFHKD AATLEPPSSA KITFQCKHTS ALSSHVLNKE DLIEDLSHPS NIEKAVDNSV
VSFTNESTYS MKYPGSLSST VHSETPHKEN SKKDILPVSS CESSIFDYEE DIPSVARQIP
NRKYTNIRKI EKDSPFIHMN RHTNENILGK NSFNFSDLKN KLSSEGNEKG NSTTLNSLFP
SSLTENCELL SCSGENRTMV HSLDSIADES GLNKLKIRYE EFQEHKTEKP SLSQQAAHYM
FFPSVVLSNC LTRPQKLSPV TYKLQPGNKP SRLKLNKKKL LCHRETSIKS SETGSTNDNC
IQNNPYNHNP EKDNILASDL IKATRGAFEN KTAADGFIDC HFADGNLEPE QSFGLYGNKY
TLRAKRKVNY ETEDSESSFV THNSKISLPH PLEIGESLDG SIKSRKRRKM SKKLPPVIIK
YIIINRFRGR KNMLVKLGKI DSTEKQVILT EEKMELYKKL APLKDFWPKV PDSPATKYPI
YPLTPKKSHR RKSKHKSTKK KTGKQQRTNG ENIKRTLSFR KKRSHAVLSP PSPSYNAETE
DCDLNYSDVM SKLGFLSERS TSPINSSPPR CWSPTDPRAE EIMAAVEKEA TLFKGPNAYK
GKTVNSRVGK NSRARAQVKR SKAKLVNPSV ATKKRSKRNQ TNKLVEDGKK KPRAKQKQKN
EKGSSRKHIT LRDEKIKSQS GAEVKFVLKH QNASELTNSS GGSQLLFKQK DVSLTGSAID
HPLPAPLPAA MNAQQKLPGC FSSFLENKSV DLQTFPSSRD DLHSSVCGSV GPGISKINIQ
RSHNQSTMFT LKESTLIQKN IFDLSNHLFQ VAQNTQISSG IMSPKTEDNA NIQKNYLSSF
GKLNEYRSSL ESKPDQAYAP NFLHCKDSQQ QIVCMAEQSK HSETCSSGNT EESQMSNNCF
VTSLRSPVKQ IAWDQKQRGF ILDMSNFKPE RVKQRSLSEA ISQTKALSQC KNQNVSTPST
LTEGQSGLAV LKELLQKRQQ KAQNANIMQD PLSNKHQPNK NTSGSLEHNK ANKRTRSVTS
PRKPRTPRNA KPKEKIPKLL KVDSLNLQNS GQLDNSLSDD SPIFFSDPGF ESCYSLEDSL
SPEHNYNFDI NTIGQTGFCS LYSGSQFVPA DQNLPQKFLS DAVQDLFPGQ TIEKSEFLSH
DNQKCDEDKH RASDSSSWIR SGTLSPELFE KSPIDNTETH RHNQWKNSFH SLTTRSNSIM
DSFCQAEDCL NEKSRLSRNS VSKEVFISLP QTSSSNWIQG HTRKEMGESL DSVNTSFTTI
LSSPDGELVD AASEDLELYV SRNNDMLTPT PDSSPRSASS PLQSKNGCFT PRTAHILKPL
MSPPSREEIV ATLLDHDLSE TIYQEPFCSN PSDVPEKPRE IGGRLLMVET RLPNDLAEFE
GDFSLEGLRL WKTAFSAMTQ NPRPGSPLRN GQAVVNKGSS NSHKMVEDKK IVIMPCKCAP
SRQLVQAWLQ AKEEYERSKK LPKIEPTGVV KSAENFSSSV NPDDKPVVPP KMDASPHICS
TTAHTKEDVD NSQIGLQVPT TEYSRTSSES QMLPSVASSN DPEKEDDDNY YISYTSPDSP
VIPPWQQITS PDSKVLNGDD RPSSPVEEQR TLAVENFVNL MKDGLQKSPY NESQEPLVIS
PINARARTGK CESLCLHSTP IIQRKLLERL SEATALSPLS TAFSAMTQNP RPGSPLRNGQ
AVVNKGSSNS HKMVEDKKIV IMPCKCAPSR QLVQAWLQAK EEYERSKKLP KIEPTGVVKS
AENFSSSVNP DDKPVVPPKM DASPHICSTT AHTKEDVDNS QIGLQVPTTE YSRTSSESQM
LPSVASSNDP EKEDDDNYYI SYTSPDSPVI PPWQQITSPD SKVLNGDDRP SSPVEEQRTL
AVENFVNLMK DGLQKSPYNE SQEPLVISPI NARARTGKCE SLCLHSTPII QRKLLERLSE
ATALSPLSTE PKTQKLSNKK GSNTDTLRRV LLTTQSKNQF AAVNTPKKET SQIDGPSLNN
TYGFKVSIQN LQEAKALHEI QNLTLISVEL HARTRRDLEP DPEFDPICAL FYCISSDTPL
PDTEKTELTG VIVIDKDKTV FSQDLRYQTP LLSRSGITGL QVTYAADEKA LFQEIANIIK
RYDPDILLGY EIQMHSWGYL LQRAAALNVD LCQMISRVPD DKIENRFSVE KDEYASDTMS
EINIVGRITL NLWRIMRNEV ALTNYTFENV SFHILHQRFP LFTFRVLSDW FDNKTDLYRW
KMVDHYVSRV RGNLQMLEQL DLIGKTSEMA RLFGIQFLHV LTRGSQYRVE SMMLRIAKPM
NYIPVTPSVQ QRSQMRAPQC VPLIMEPESR FYSNSVLVLD FQSLYPSIVI AYNYCFSTCL
GHVENLGKYD EFKFGCTSLR VPPDLLYQIR HDVTVSPNGV AFVKPSVRKG VLPRMLEEIL
KTRFMVKQSM KAYKQDRALS RMLNARQLGL KLIANVTFGY TSANFSGRMP CIEVGDSIVH
KARETLERAI KLVNDTKKWG ARVVYGDTDS MFVLLKGATK EQSFKIGQEI AEAVTATNPK
PVKLKFEKVY LPCVLQTKKR YVGYMYETLD QKDPVFDAKG IETVRRDSCP AVSKILERSL
KLLFETRDIS LIKQYVQRQC MKLLEGKASI QDFIFAKEYR GSFSYKPGAC VPALELTRKM
LTYDRRSEPR VGERVPYVII YGTPGIPLIQ LVRRPVEVLQ DPTLRLNATY YITKQILPPL
ARIFSLIGID VFSWYHELPR IQKATSSSRS ETEGRKGTIS QYFTTLHCPV CDDLTQHGIC
SKCRSQPQHV AVILNQEIRE MERKQEQLVK ICKNCTGCFD RHIPCVSLNC PVLFKLSRVN
RELSKAPYLR QLLDQF
//
