ID L9JW49_TUPCH Unreviewed; 462 AA.
AC L9JW49;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Beclin-1 {ECO:0000313|EMBL:ELW54716.1};
GN ORFNames=TREES_T100019598 {ECO:0000313|EMBL:ELW54716.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW54716.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SIMILARITY: Belongs to the beclin family.
CC {ECO:0000256|ARBA:ARBA00005965}.
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DR EMBL; KB320934; ELW54716.1; -; Genomic_DNA.
DR AlphaFoldDB; L9JW49; -.
DR STRING; 246437.L9JW49; -.
DR eggNOG; KOG2751; Eukaryota.
DR InParanoid; L9JW49; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR Gene3D; 6.10.250.3110; -; 1.
DR Gene3D; 1.10.418.40; Autophagy protein 6/Beclin 1; 1.
DR InterPro; IPR007243; Atg6/Beclin.
DR InterPro; IPR038274; Atg6/Beclin_C_sf.
DR InterPro; IPR041691; Atg6/beclin_CC.
DR InterPro; IPR040455; Atg6_BARA.
DR PANTHER; PTHR12768; BECLIN 1; 1.
DR PANTHER; PTHR12768:SF6; BECLIN-1; 1.
DR Pfam; PF04111; APG6; 1.
DR Pfam; PF17675; APG6_N; 1.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 147..273
FT /note="Atg6/beclin coiled-coil"
FT /evidence="ECO:0000259|Pfam:PF17675"
FT DOMAIN 276..457
FT /note="Atg6 BARA"
FT /evidence="ECO:0000259|Pfam:PF04111"
FT REGION 47..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 157..279
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 462 AA; 53187 MW; 7FECD6093DFB2588 CRC64;
MEGSKTSSST MQVSFVCQRC SQPLKLDTSF KILDRVTIQE LTAPLLATAQ TKPGETQEDE
ANSGEEPFIE TRQDGVSRRF IPPARMMSTE SANSFTLIGE ASDGGTMENL SRRLKASRPP
SHVRQQAQLV TGDLFDIMSG QTDVDHPLCE ECTDTLLDQL DTQLNVTENE CQNYKRCLEI
LEQMNEDDSE QLQMELQELA LEEERLIQEL EDVEKNRKVV AENLEKVQAE AERLDQEEAQ
YQREYSEFKR QQLELDDELK SVENQMRYAQ MQLDKLKKTN VFNATFHIWH SGQFGTINNF
RLGRLPSVPV EWNEINAAWG QTVLLLHALA NKMGLKFQRY RLVPYGNHSY LESLTDKSKE
LPLYCSGGLR FFWDNKFDHA MVAFLDCVQQ FKEEVEKGET RFCLPYRMDV EKGKIEDTGG
SGGSYSIKTQ FNSEEQWTKA LKFMLTNLKW GLAWVSSQFY NK
//
