ID L9KJU4_TUPCH Unreviewed; 870 AA.
AC L9KJU4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial {ECO:0000313|EMBL:ELW63016.1};
GN ORFNames=TREES_T100001772 {ECO:0000313|EMBL:ELW63016.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW63016.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR EMBL; KB320797; ELW63016.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KJU4; -.
DR STRING; 246437.L9KJU4; -.
DR eggNOG; KOG2844; Eukaryota.
DR InParanoid; L9KJU4; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR13847:SF193; PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Pyruvate {ECO:0000313|EMBL:ELW63016.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 44..401
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 405..459
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 461..727
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 756..844
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 870 AA; 98282 MW; 5895BC609EB2008B CRC64;
MFYRLLSVVR RRRTSPGWQN WPSARSNASS AAAPSAALPA QAQVVICGGG IMGTSVAYHL
SKMGWTDIVL VEQGRLAAGS TRFCAGILST ARHLTIEQKM ADYSNKLYQQ LEQETGIQTG
YIKTGSIYLA QTQDRLISLK RINSRLNVMG IPSEIISPKK VAELHPLLNV HDLVGAMHVP
EDAVVSSADV ALALASAASQ NGVQIYDRTT VLHVMVKQGQ VTGVETDKGQ IECQYFVNCA
GQWAYELGLS NEEPVSIPLH ACEHFYLLTR PLETPLQSDT PTIVDADGRV YIRNWQGGIL
SGGFEKNPKP IFTEGKNQLE IQNLQEDWDH FEPLLSSLLR RMPELETLEI MKLVNCPETF
TPDMRCIMGE SPVVQGYFVL AGMNSAGLSF GGGAGKFLAE WMVYGYPSEN IWELDLKRFG
ALQSSRTFLR HRVMEVMPLM YDLKVPRWDF QTGRQLRTSP LYDRLDAQGA RWMEKHGFER
PKYFVPPDKD LLALEQSKTF YKPDWFDIVE SEVKCCKEAV CVIDMSSFTK FEITSTGDQA
LEILQYLFSN DLDVPVGHIV HTGMLNQGGG YENDCSIARL NKRRYPVGSR NLMLKHMPKD
TDLLLEDVTW KYTALNLIGP RAVDVLSELS YAPMTPDHFP SLFCKEMSVG YANGIRVMSM
THTGEPGFML YIPIEYALHV YNEVMSVGQK YGIRNAGYYA LRSLRIEKFF AFWGQDLNTL
TTPLECGRES RVKLDKGMDF IGREALLQQK QNGVYKRLTM FILDDHDTDL DLWPWWGEPI
YRNGLYVGKT TSSAYSYTLE RHVCLGFVHN FSEDTGEEQV VMADFINRGE YEIDIAGHRF
QAKAKLYPVA SLFTHKRRKD DVELSDLHGK
//
