ID L9KL68_TUPCH Unreviewed; 328 AA.
AC L9KL68;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=L-serine ammonia-lyase {ECO:0000256|ARBA:ARBA00012093};
DE EC=4.3.1.17 {ECO:0000256|ARBA:ARBA00012093};
DE AltName: Full=L-serine deaminase {ECO:0000256|ARBA:ARBA00041766};
DE AltName: Full=L-threonine dehydratase {ECO:0000256|ARBA:ARBA00042605};
GN ORFNames=TREES_T100009959 {ECO:0000313|EMBL:ELW63715.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW63715.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169,
CC ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00001161};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; KB320764; ELW63715.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KL68; -.
DR STRING; 246437.L9KL68; -.
DR eggNOG; KOG1250; Eukaryota.
DR InParanoid; L9KL68; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR CDD; cd06448; L-Ser-dehyd; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR PANTHER; PTHR48078:SF8; L-SERINE DEHYDRATASE_L-THREONINE DEAMINASE; 1.
DR PANTHER; PTHR48078; THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF00291; PALP; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 9..303
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
SQ SEQUENCE 328 AA; 34482 MW; FCE91E35B274EDF2 CRC64;
MTSGEPLHVK SPLRDSMTLS KEAGTCVYLK LDSAQPAGSF KIRGIGHLCR TWAERGCEHF
VCSSAGNAGM ATAYAARKLG IPATIVVPST TPAVTIKRLK NEGAMVRVVG ETLDEAFELA
KALAKNNPGW VFIPPFDDPL IWEGHTSIVK ELKETMGTKP GAIALSVGGG GLLCGVVQGL
QEVGWGDVPV IAMETIGAHS FHATATAGKL VSLPQLTSVA TALSVKTVAA QTLKLFQEHP
IFSEVVSDQE AVAAIEKFVD DEKILVEPAC GAALAAVYSH VVQKLQGEGK LQAPLPSLVV
IVCGGSNISL AQLQALKEEV AKRERLSK
//
