ID L9KN89_TUPCH Unreviewed; 2900 AA.
AC L9KN89;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Extracellular matrix protein FRAS1 {ECO:0000313|EMBL:ELW63934.1};
GN ORFNames=TREES_T100007710 {ECO:0000313|EMBL:ELW63934.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW63934.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR EMBL; KB320758; ELW63934.1; -; Genomic_DNA.
DR STRING; 246437.L9KN89; -.
DR InParanoid; L9KN89; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005840; C:ribosome; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd00064; FU; 7.
DR Gene3D; 2.60.40.2030; -; 3.
DR Gene3D; 6.20.200.20; -; 3.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR000915; 60S_ribosomal_eL6.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR005568; Ribosomal_uL6_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR45739:SF1; EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 3.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01159; Ribosomal_L6e; 1.
DR Pfam; PF03868; Ribosomal_L6e_N; 1.
DR Pfam; PF00093; VWC; 3.
DR SMART; SM00237; Calx_beta; 3.
DR SMART; SM00261; FU; 9.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 2.
DR SUPFAM; SSF141072; CalX-like; 3.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS51854; CSPG; 12.
DR PROSITE; PS01208; VWFC_1; 4.
DR PROSITE; PS50184; VWFC_2; 6.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 54..102
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 107..167
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 171..231
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 233..293
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 297..402
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 406..476
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REPEAT 924..1019
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1039..1130
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1138..1247
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1272..1367
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1358..1453
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1474..1574
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1597..1700
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1721..1821
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1842..1941
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1963..2055
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2075..2168
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2201..2298
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2697..2737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2697..2720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2900 AA; 319499 MW; DAA890FF86D062BF CRC64;
MAREEYLQEA DGSPVRLRAS QDGSRGWESG PPLVAQLSLV STLCDPRVVS DATVWKPDSC
QYCRCHGDIV ICKPAVCRNP QCAFEKGEVL QIAANQCCPE CVSRTPGSCH HENKIHEHGT
EWASSPCSVC SCSHGEVRCT PQPCPPLSCG HQELEFIPEG SCCPICVGPG KPCSYEGRVF
QDGEDWQLSR CAKCVCRNGA VQCFTAQCQP LFCNQDETVV RVSGKCCPQC SSQSCSAAGQ
VYEHGEQWSE NVCTTCACDR GEVRCHKQAC PPLRCEKGQN RARLHGQCCE ECVSPTGSCL
YDGIMRYQDE MWKASACEFC TCDRGQVTCQ TAGCAKVECA RLVRLEALSQ KHNGEGRDAD
ISLSAGAAGP HCCWPALAVV VHQGPQGEEL IHLDGKCCPE CMSRNGHCVY EERAEFISSN
TSEIKHIPEG EKWEGGPCKV CECQGAQVTC YEPSCAPCPV ATLALVVKGQ CCPDCTSACQ
PWCSTCASGL ECSSCQPPLL MQLGHCVSTC GDGFYRDRHT CAVCHESCVS CWGPTEKHCL
ACREPLQVLR EGSCVTSCGE GFYNRQGTCS ACDQSCKSCG PNSPRCLTCT EKTVLHDGKC
ISECPGGYYA DANGRCKACH SSCLTCVGPE PAHCTGCKKP EEALQAVQLP GAGVPWGTCL
SQCEAQFYLE STGLCEDCHP LCQHCAAHLH STGSICLRCQ SVRHLLLGDH CVSDCPSGYY
AEMGACKKCH SSCKTCQGRG PFSCSSCDTN LVLSHLGTCS TTCFPGHYLD DNRACQPCDT
HCRSCDSQAS CTSCRDPNKV LLFGECQYES CAPQYYLDFS TNTCKECDWS CNACSGPLRT
DCLQCMDGYF LQDGACVEQC APAFYRDVGL CKSCDNHCVQ CQGPQECTRC EEPFLLLEAQ
CVQECGKGYF ADHAKHKCTG KIHTPSLHVN GSLTLAIGSM KPLDFSLLNI QDQDGRVEDL
LFHVVSTPTN GQLVLSRNGK EIQLDKAGHF SWKDVNKKKV RFVHSKEKLR KGYFSLKISD
QQFFSEPQLI NIQAFSTQAP YVLRNEALHI SRGERGTITT HLLDIRDDDN PQDVVVEVLD
PPLHGQLLQT LQSPATPVYQ FRLDELSRGL LLYAHDGSSS TSDVAVLQAN DGHFNDGGLR
LVANSMVWVP EGGMLQITNR ILQAEAPGTS AEEIIYKITQ DHPKFGEVVL LVNMPADSPT
DQGQHLPDGR TATPTSTFTQ QDIDEGIVWY RHSGAPAQSD AFRFQVSRAT DAHTHLESRM
FNIAILPQTP KAPKLSLGTS LHMTAREDGL TVIQPHSLSF VSERPSGKIL YNITVPLHPN
QGIIEHRDQP LSPIRYFTQD DINQGKIMYR PPTAAPHLQE LMAFSFAGLP ESVKFHFTVL
RLVIRDTKTA SEELVFELRK PPLHGVLLKY TAEFQGPMAT GDTFTYKDIE ENALHYIHDG
SPAQEDSMEI SVTDGITTTT SEVRVEVSLS EDQRPRLAAG SSLSITVASK SSAVITRSHL
AYIDDSSPDP EIWIRLSSLP TYGVLLRTIG PEVEELSEVS NFTMEDINNK NIRYSAVFDT
NGHPVTDRFH FSVSDMDHNQ LENQIFTIMI TPAENPPPLI AFADLITVDE GGRAPLSFHH
FFATDDHDNL QGDAVIKLSA LPKYGCIENT GTGDRFGPGA TSDLEASFPI QDVLENYIYY
FQSVHESVEP THDIFSFYVS DGTSRSEIHS INITIERKND EPPRMTLRPL RVQLSSGVVI
SNSSVSLQDL DTPENELIFV LTKVPDHGHL LRRLTAFEPL KNGTALVHGS SFSYQDILAG
LVGYVPGDSS MAVDEFRFSL TDGLHVDSGR MEIYMELLTS GSPHLAVSRG LQLSAGSIAR
ITEQHLKVTD TDSAEHQVVY IMKEDPGAGR LQMAKHDDLE QISIKGPLRS FTQADINQGH
VEYRHATGEP SGSFAFKFDV VDGEGNKLSD QSFSIHVLED KAPPVIITNK GLVLDENSVR
KITTQQLSAT DQDSEPAELT YRITRQPQLG RLEHAASPGI QISSFTQADL TSRNIQYIHS
SETEKHSDAF TFVLSDGGHE VTQTFHITLR PVDDSLPIVK NLGMRVQEGV RKTITEFELK
AVDADTEAES VTFTIVQPPR HGTIERTANG QHFRLTSTFT MEDIYQNQIS YSHDGSNSIK
DRFTFTVSDG TNPFFIVEEG GKETAAPQQF RVDILPVDDG TPRIVTNLGL QWLEYMDGKA
TNLITKKELL TTDPDTEDLQ LVYEITTGPK HGYVESKLQP GRAVASFTQE DVNLGLIRYV
LHEEKIHEMM DSFQFLVKDS KPNVVSDNVF HIQWSLISFK YTSYNVSEKA GSVSVTVQRT
GNLNQYAIVL CRTEQGTASS SSRVNFQPGQ QDYVEYAGQV QFDEREDTKS CTIVINDDDV
FENVESFTVE LSMPAYALLG DFTQAKVIIN DTEDEPTLEF DKKTYRVNES AGFLFAPVER
KGDSSSIVSA ICYTIPKSAM GSSLYALESG SDFKSRGRTA ESRVIFGPGV TMSTCDVMLI
DDSEYEEEEE FEIVLADASD NARIGKVAMA KVFIGGPNDA STVSLSNTAF TVSEDAGTVK
IPVIRHGTDL STFTSVWCAT RPSDPASATP GVDYVPSSRK VEFGPGITEQ YCTLTILDDT
QYPVIEGLET FVVFLSSAQG AELTKPFQAV IAINDTFQDG LEFSFPIYKM AGEKVVERDT
KEKKPEAKKA DASGQVKKGD PKAKKPKKGK PHCSRNPVLV QGFSRYSPSA MSSRKAAYRR
KYSATKSRIE KKKKEKVLTT VTKPVGGDKN GGTRVVKLCK MPRTHQKFVI ATSMKIDISK
VKISKHLTDA YFKKKKLWKP RHQEDETFDI EKEKYEQRKV HQKAVDSQIF TKIKAVPQLQ
GYLRSVFALT NGVYPHKLVL
//
