ID L9KP26_TUPCH Unreviewed; 1124 AA.
AC L9KP26;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Rho GTPase-activating protein 20 {ECO:0000313|EMBL:ELW64234.1};
GN ORFNames=TREES_T100013203 {ECO:0000313|EMBL:ELW64234.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW64234.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB320750; ELW64234.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KP26; -.
DR STRING; 246437.L9KP26; -.
DR eggNOG; KOG4724; Eukaryota.
DR InParanoid; L9KP26; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13319; PH_RARhoGAP; 1.
DR CDD; cd17115; RA_RHG20; 1.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR047887; ARHGAP20_PH.
DR InterPro; IPR047888; ARHGAP20_RA.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23179:SF28; RHO GTPASE-ACTIVATING PROTEIN 20; 1.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 144..233
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 315..501
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 713..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 998..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1015
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1068
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1124 AA; 124694 MW; A3F8DBD310B35AC3 CRC64;
MKTLAERRRS APSLILDKAL QKRPSTRESP AASVDTCAFL SSFVCSSRTL LIDGRVELRR
GLQRQERHLF LFNDLFVVAK IKYNNNFKIK NKIKLTDMWT ASCVDEVGEG NTNAMKSFVL
GWPTVNFVAT FRYINLEKEK DYPKSIPLKI FAKDIGNCAY SKTITVMNSD TANEVINMSL
PLLGITGSER DYQLWVNSGK EEAPYPLIGH EYPYGIKMSH LRDTVLLTQG SKDSSTPVNP
QEPFLMEQLP REMQCQFILK PSRLAAAQHL SDSGQKTFKR RRSIINWAFW RGSSTHLDNV
PVSPTSPRPG QLFGVSLLNI CENDNLPKPV LDMLFLLNQK GPLTKGIFRQ SANVKSCREL
KEKLNSGVEV HLDCESIFVI ASVLKDFLRN IPGSIFSSDL YDHWVCVMDQ GNDEEKINTI
QRLLDQLPRA NVVLLRYLFG VLHNIEQHSS SNQMTAFNLA VCIAPSILWP PSSSSPELEN
EFTKKVSLLI QFLIENCCRI FGEEITSLLG EVSVRCDARE NVSDISCFQL NDSSYDSLEN
ELNEDVDAPC SDLVKKLGQG SRSMDSVLTL SDYDLDQPEV EGLLTLSDFD LDHSKNEDLQ
VKAPLESKLL NVLVYTKIPL RDHARTPSGT CSRSCLSTAA ADAPKSLRRH RRCSEPSIDY
LDSKLSYLRE FYQKKLRKSS CDAILSQKDE DNPKQDQPLQ EEGKACLKHS LVVGTDSKKN
ATPQNVKKKS LPGNEGNHGK PFPKSKPVAI SVASYSRMPS QDHSRNQSFD MTTSGYSPPH
TADVLKNSRT HRRCSEPNID DQHCKLTYLR GIYSKKQHKT SCEAGFLHRE EDYLKRHKSL
QMEGQKLINQ SLVMGIEVGK SSAITQSTEK VLPPRLNLCP RTSFSSLSSP GTSPSGSVSS
QDSAFSQISE HSVFTPTETS SPIDCTFQAR RKLEELSSDF SSSIPISGMP GPSSGQASSL
LPSTKKDTGE WHSQIHSVTL HPSTWLRNGV ASLKNWSLKK KAKTAKPDEK EIGSLKGPSE
PPPLASFVPE ASSLQERQKD LPLGVAEGAG TVQTAQWDSS PCQDSEKHCS SPFSLVESRL
QLCTKSQEEV QPGGQCPSGA LPGERTSSSS VTVGNVSTLA GTDL
//