ID L9KQF6_TUPCH Unreviewed; 1007 AA.
AC L9KQF6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Microprocessor complex subunit DGCR8 {ECO:0000313|EMBL:ELW64709.1};
GN ORFNames=TREES_T100000631 {ECO:0000313|EMBL:ELW64709.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW64709.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB320718; ELW64709.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KQF6; -.
DR STRING; 246437.L9KQF6; -.
DR eggNOG; KOG4334; Eukaryota.
DR InParanoid; L9KQF6; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0070877; C:microprocessor complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031053; P:primary miRNA processing; IEA:InterPro.
DR CDD; cd19867; DSRM_DGCR8_rpt1; 1.
DR CDD; cd19868; DSRM_DGCR8_rpt2; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.30.160.20; -; 3.
DR Gene3D; 3.30.160.590; -; 1.
DR InterPro; IPR040375; DGCR8.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR13482:SF3; MICROPROCESSOR COMPLEX SUBUNIT DGCR8; 1.
DR PANTHER; PTHR13482; MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8; 1.
DR Pfam; PF00035; dsrm; 1.
DR SMART; SM00358; DSRM; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 282..315
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 492..559
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1007 AA; 110448 MW; E1F353D9F0CE173C CRC64;
MLENRACPFQ VLPREQSPPP PLQTSSDAEV MDVGSGGDGQ SEPPAEDPFN FYGASLLSKE
PFSKGRLLID PNCSGHSPRT ARHAPAVRKF SPDLKLLKDV KISVSFTESC RSKDRKVLYT
GAERHARADG GALLSPGSGD VHACPFGGSV GNGVGGGGES ADKKDEDELD QEKRVEYAVL
DELEDFTDTL ELDEEGAGGF TAKAIVQRDR VDEEALNFSY EDDFDNDVDA LLEEGLCAPK
KRRIEEKYGG DSDHPSDGET SVQPMMTKIK TVLKSRGRPP TEPLPDGWIM TFHNSGVPVY
LHRESRVVTW SRPYFLGTGS IRKHDPPLSS IPCLHYKKMK DNEEREQNSE LTPSGEVSPA
KPLSRSAELE FPLEEPDPTG ADSGPPDEKD LLGAEATPGA LGQVKAKVEV CKDESVDLEE
FRNYLEKRFD FEQVTVKKFR TWAERRQFNR EMKRKQAESE RPILPANQKL ITLSVQDAPT
KKEFVINPNG KSEVCILHEY MQRVLKVRPV YNFFECENPS EPFGASVTID GVTYGSGTAS
SKKLAKNKAA RATLEILIPD FVKQTSEEKP KDSEELEYFN HISIEDSRVY ELTSKAGLLS
PYQILHECLK RNHGMGDTAI KFEVVPGKNQ KSEYVMACGK HTVRGWCKDP LPHPCGPSSV
QMTRVVPGCC PQRGLTPSPS SECWCHTWSR GGAGLPLLPC PSCRVPAAAA PALQACPCGK
EPLAEISLYF LKQPCVTMQR HASSDGEGPG PGKPRWPPTA RSTELRSCRA AMGSRAGGKN
KRVGKQLASQ KILQLLHPHV KNWGSLLRMY GRESSKMVKQ ETSDKSVIEL QQYAKKNKPN
LHILSKLQEE MKRLAEEREE TRKKPKMSIV ASAQPGGEPL CTVDVQRVRG PGPGVEALGR
ACHGHSTCVL GGCAQLWVDV QGPSPSAPVE PAAHGPCRAP PAGCPYEGVL MNFSLQYTLR
SGSWTDGLRP VAVAGLQGRV AHAQGSQEHR RALSEAHAAP AFCVFRL
//
