ID L9KQI5_TUPCH Unreviewed; 469 AA.
AC L9KQI5;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Natural cytotoxicity triggering receptor 1 {ECO:0000256|ARBA:ARBA00040484};
DE AltName: Full=Natural killer cell p46-related protein {ECO:0000256|ARBA:ARBA00041225};
GN ORFNames=TREES_T100020630 {ECO:0000313|EMBL:ELW64739.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW64739.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the natural cytotoxicity receptor (NCR) family.
CC {ECO:0000256|ARBA:ARBA00006531}.
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DR EMBL; KB320717; ELW64739.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KQI5; -.
DR STRING; 246437.L9KQI5; -.
DR eggNOG; ENOG502RWVC; Eukaryota.
DR InParanoid; L9KQI5; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd16843; IgC2_D1_D2_LILR_KIR_like; 1.
DR CDD; cd05751; IgC2_D1_LILR_KIR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR PANTHER; PTHR11738:SF14; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|EMBL:ELW64739.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 107..192
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 223..307
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 322..404
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
SQ SEQUENCE 469 AA; 51194 MW; 435790AAE9CDCE1D CRC64;
MHRIFPTPVI SASPSSLIPW NGSVKILCQG TPESYLYQLV ILGNASYKEV EKRLGIQKEA
EFVIKHMDTT TAGRLQCRYM KQYRWSEYSE ALELVVTGLF DKPLLSAEQG VVRLGAKIYL
RCGSAHVPFD SFSLAKDGEA SLPPPQHRGP QGSFTLGPVN RSFSGNYRCY GWHSGSPYVW
SAPSNALELV VTALAALLCL GLCLSRRIST QTQTLSKPTI WAKPDFMVPK GKPVAIWCRG
APKAAEFQLY FEGSLSAVER PRTPGPLNQV KFLISAMSSQ TAGQYSCSYW TGELWSEPSH
TLDLVVTGMY EDEDDVPTLS VLPGPEVTSG DSVTFCCHLQ TATSTFFLVK EGRPSHVQKK
HGTTRAEFPV GLVTTAHQGT YRCFGSYNNH AWSLPSKPVK LVVTAGLEGP RLSEPAGAAA
WCCGQRPGLC LREAGSALPV GGLVLQGQLE ARMWGGPTWH QEPEPEPEG
//
