UniProt: L9KS40

Database: UniProt
Entry: L9KS40_TUPCH

LinkDB:  L9KS40_TUPCH 
Original site:  L9KS40_TUPCH

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Ontology (6)   
   GO (6)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (38)   
   InterPro (18)   
   Pfam (8)   
   PROSITE (6)   
   SMART (6)   
Literature (1)   
   PubMed (1)   
All databases (46)   

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ID   L9KS40_TUPCH            Unreviewed;      1064 AA.
AC   L9KS40;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Guanine nucleotide exchange factor VAV3 {ECO:0000313|EMBL:ELW65319.1};
GN   ORFNames=TREES_T100013991 {ECO:0000313|EMBL:ELW65319.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW65319.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
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DR   EMBL; KB320697; ELW65319.1; -; Genomic_DNA.
DR   AlphaFoldDB; L9KS40; -.
DR   STRING; 246437.L9KS40; -.
DR   eggNOG; KOG2996; Eukaryota.
DR   InParanoid; L9KS40; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005840; C:ribosome; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0051716; P:cellular response to stimulus; IEA:UniProt.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   CDD; cd20869; C1_VAV3; 1.
DR   CDD; cd01223; PH_Vav; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd10407; SH2_Vav3; 1.
DR   CDD; cd11981; SH3_VAV3_1; 1.
DR   CDD; cd11978; SH3_VAV3_2; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 2.
DR   InterPro; IPR035970; 60S_ribosomal_eL19_sf.
DR   InterPro; IPR022613; CAMSAP-like_CH_dom.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037832; PH_Vav.
DR   InterPro; IPR000196; Ribosomal_eL19_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR035881; VAV3_SH2.
DR   InterPro; IPR047015; VAV3_SH3_1.
DR   InterPro; IPR035734; VAV3_SH3_2.
DR   PANTHER; PTHR45818:SF1; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3; 1.
DR   PANTHER; PTHR45818; PROTEIN VAV; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF11971; CAMSAP_CH; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF01280; Ribosomal_L19e; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF07653; SH3_2; 2.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM01416; Ribosomal_L19e; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 2.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48140; Ribosomal protein L19 (L19e); 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF50044; SH3-domain; 2.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 2.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          410..588
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          617..719
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          730..779
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          809..877
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          889..983
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          1005..1064
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          113..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          784..807
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1064 AA;  120825 MW;  8AA7799249E3A724 CRC64;
     MGLLALEGEL TPILVQMVKS ANMNGLLDSD GDSLSSCQHR VKARLHHILQ QDAPFGPEDY
     DQVLPANHRV TWDSAQVFDL AQTLRDGVLL CQLLNNLRAH SINLKEINLR PQMSQSAGGQ
     SSRKNRYVSD DSHRHPGFVL GTVNTGRYSE SLPLPRVVCN LLPRIKAFSS SQGLRDPSCC
     VGSPCSCVQA HVLVQAFCVL CGGKKKAWLD PSETNEVANA SSHQQIRKLI KDGLIIRKSV
     TVHSQAPCWK YSLAQRKGRP MGLAGWRYLR VISAGRLPLA GADACMFLCL KNIRTFLTAC
     CETFGMRKSE LFEAFDLFDV RDFGKVIEAL SRLSRTPIAL ATGIRPFPTE ESVNDEDIYK
     GLPDLIDETR VDDEEDLYDC VYGEDEGGEV YEDLMKAEEA HQSKCLENDI RSCCLAEIKQ
     TEEKYTETLE SIEKYFMAPL KRFLTAAEFD SVFINIPELV KVHRSLMQEI HDSIVNKNDQ
     NLYQVFINYK ERLVIYGQYC SGVESAISSL DYISKTKEDV KLKLVIYGQY CSGVESAISS
     LDYISKTKED VKLKLEELVK HTTDPTEKAN LKQALDAMKD LAQYVNEVKR DNETLREIKQ
     FQLSIENLNQ PVLLFGRPQG DGEIRITTLD KHTKQERHIF LFDLAVIVCK RKGDNYEMKE
     IIDLQQYKIA NNPTTDKENK KWSYGFYLIH TQGQNGLEFY CKTKDLKKKW LEQFEMALSN
     IRPDYADSNF HDFKMHTFTR VTSCKVCQML LRGTFYQGYL CFKCGARAHK ECLGRVDNCG
     RVNSGEQGTV KPPEKRTNGL RRTSRQMDPG LPKMQVIRNY TGTPPPALHE GPPLHIQAGD
     TVELLRGDAH SLFWQGRNLA SGEVGFFPSD AVKPSPCVPK PVDYSCQPWY AGAMERLQAE
     TELINRVNST YLVRHRTKES GEYAISIKYN NEAKHIKIVT RDGFFHIAEN RKFKSLMELV
     EYYKHHSLKE GFRTLDTTLQ FPYKEPEHSA GQRGNRAGNS LLSPKVLGIA IARYDFCARD
     MRELSLLKGD VVKIYTKMSA NGWWRGEVNG RVGWFPSTYV EEDE
//

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