ID L9KSE2_TUPCH Unreviewed; 1169 AA.
AC L9KSE2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Integrin alpha-2 {ECO:0000313|EMBL:ELW65711.1};
GN ORFNames=TREES_T100005285 {ECO:0000313|EMBL:ELW65711.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW65711.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; KB320678; ELW65711.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KSE2; -.
DR STRING; 246437.L9KSE2; -.
DR eggNOG; KOG3637; Eukaryota.
DR InParanoid; L9KSE2; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 3.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF23; INTEGRIN ALPHA-2; 1.
DR Pfam; PF01839; FG-GAP; 3.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 6.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 2.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1122..1146
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 12..70
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 152..339
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 455..517
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 518..565
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 566..624
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 630..690
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1169 AA; 128462 MW; 8866F9BBAF695930 CRC64;
MLNCCLAYNV GLPEAKIFSG PSSEQFGYAV QQFINPKGNW LLVGSPWSGF PENRMGDVYK
CPLDLSTTTC EKLNLQTSTS IPNVTEMKTN MSLGLTLTRN VGTGGFLTCG PLWAQQCGNQ
YYTTGVCSDV SPDFQLLASF SPAVQTCPSL VDVVVVCDES NSIYPWEAVK NFLEKFVQGL
DIGPTKTQVG LIQYANDPRV IFDLNTFKTK DEMILATSKT AQRGGDLTNT FKAIQFARDF
AYSPASGGRP SATKVMVVVT DGESHDGSRL KAVIDQCNND NILRFGIAVL GYLNRNALDT
KNLIKEIKAI ASIPTERYFF NVSDEAALLE KAGTLGEQIF SIEGTVQGGD NFQMEMSQVG
FSADYSPQND ILMLGAVGAF GWSGTVVQQT PHNHWIFPKQ AFDQILQDKN HSSYLGYSVA
AITTGKNVYF VAGAPRANYT GQIVLYSVNK NGNVTVIQAH RGDQIGSYFG SVLCSVDVDK
DTITDVLLVG APMYMNDLKK EEGRVYLFTI IKIGSYFGSV LCSVDVDKDT ITDVLLVGAP
MYMNDLKKEE GRVYLFTIIK GVLNQHQFLE GPEGIENARF GSAIAALSDI NMDGFNDVIV
GSPLENQNSG AVYIYNGHQG TIRTKYSQKI LGSNGAFKSH LQYFGRSLDG YGDLNGDSIT
DVSIGAFGQV VQLWSQSIAD VAVEASFTPE KITLFNKNAQ IILQLCFSAK FRPIKQSNQV
AIVYNITLDA DGFSSRVTSR GLFKENNERY MKKTTVVTQT QRCTDHIIHI QEPSDVVNPL
DLRVDISLEK PGTSPALEAY SEAAKVFSLP FYKDCGDDGL CISDLVLAVQ QPSATQEKTF
IVSNQNKRLT FLVTLKNQKE SAYNTRIVVE FSENLFFASF SMPVDGTEVA CQVASSQTSV
ACGVGYPALK QEQQVTFTIN FDFNLQNLQN QASVSFQALS ESQEENEADN LVNFKIPLLY
DAEIHITRST NINFYEVSSD GNVPSIVHNF EDIGPKFIFS LKVTTGSVPI SMASVIIHIP
QYTKEKNPLM YLTGVHTDQA GDISCNADIN PLKIGQTPSS VSFKSENFRH IKELSNFQTV
QLTAAAEIDT YNPQIYVIEE NIVTIPLMIM KPHEKAEVPT GVIVGSIIAG ILLLLALVAI
LWKLGFFKRK YEKMTKSSEE IDETTELNS
//
