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Database: UniProt
Entry: L9KSS9_TUPCH
LinkDB: L9KSS9_TUPCH
Original site: L9KSS9_TUPCH 
ID   L9KSS9_TUPCH            Unreviewed;       638 AA.
AC   L9KSS9;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   10-MAY-2017, entry version 28.
DE   RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE            EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN   ORFNames=TREES_T100008958 {ECO:0000313|EMBL:ELW65529.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW65529.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: [a protein]-serine/threonine phosphate + H(2)O
CC       = [a protein]-serine/threonine + phosphate.
CC       {ECO:0000256|RuleBase:RU004273, ECO:0000256|SAAS:SAAS00324755}.
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC       {ECO:0000256|RuleBase:RU004273, ECO:0000256|SAAS:SAAS00534268}.
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DR   EMBL; KB320685; ELW65529.1; -; Genomic_DNA.
DR   ProteinModelPortal; L9KSS9; -.
DR   InParanoid; L9KSS9; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.21.10; -; 2.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   InterPro; IPR031675; STPPase_N.
DR   InterPro; IPR031844; VGPC1_C.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF00149; Metallophos; 2.
DR   Pfam; PF16891; STPPase_N; 1.
DR   Pfam; PF16799; VGPC1_C; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   SUPFAM; SSF56300; SSF56300; 2.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Hydrolase {ECO:0000256|RuleBase:RU004273,
KW   ECO:0000256|SAAS:SAAS00414742};
KW   Manganese {ECO:0000256|SAAS:SAAS00414743};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00414745};
KW   Protein phosphatase {ECO:0000256|SAAS:SAAS00414741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    445    464       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    476    502       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    514    533       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      105    110       SER_THR_PHOSPHATASE.
FT                                {ECO:0000259|PROSITE:PS00125}.
FT   DOMAIN      182    187       SER_THR_PHOSPHATASE.
FT                                {ECO:0000259|PROSITE:PS00125}.
SQ   SEQUENCE   638 AA;  73943 MW;  44200002D37B420F CRC64;
     MLVRGSKPGK NVQLQENEIR GLCLKSREIF LSQPILLELE APLKICGDIH GQYYDLLRLF
     EYGGFPPESN YLFLGDYVDR GKQSLETICL LLAYKIKYPE NFFLLRGNHE CASINRIYGF
     YDECDIHGQY YDLLRLFEYD SFPLESNYLF LGDYVDRGKQ SLETICLLLA YKIKYPENFF
     LLRGNHECAS INRIYGFYDE CKRRYNIKLW KTFTDCFNCL PIAAIVDEKI FCCHGGLSPD
     LQSMEQIRRI MRPTDVPDQG LLCDLLWSDP DKDVLGWGEN DRGVSFTFGA EVVAKFLHKH
     DLDLICRAHQ VVEDGYEFFA KRQLVTLFSA PNYCGEFDNA GAMMSVDETL MCSFQAVTRR
     AKRAPAERMS KFLRHFTVVG DDYHTWDINY KKWENEEDEE EEPPVPAPGE EGSAVSEPTS
     DSTPRPSPDF RSTLRKLFSS HRFQVIIICL VVLDALLVLA ELVLDLKIIQ PDENNYAVTV
     FHFMSIAILF FFMVEIFFKL HVFRLEFFHH KFEILDAIVV VISFILDIVL LFREHELEAL
     GLLILLRLWR VARIINGIII SVKTRSEQQL LRLKQMNIQL AAKIQHLEFS CSEKGSLSDC
     HIPLMKLKSS IGLLLQQEQE IERLNKLLKQ HGLLSEIN
//
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