ID L9KY96_TUPCH Unreviewed; 1083 AA.
AC L9KY96;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Ras-related protein Rab-44 {ECO:0000313|EMBL:ELW66117.1};
GN ORFNames=TREES_T100014807 {ECO:0000313|EMBL:ELW66117.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW66117.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB320663; ELW66117.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KY96; -.
DR STRING; 246437.L9KY96; -.
DR eggNOG; KOG0078; Eukaryota.
DR InParanoid; L9KY96; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd00637; 7tm_classA_rhodopsin-like; 1.
DR CDD; cd00154; Rab; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47977; RAS-RELATED PROTEIN RAB; 1.
DR PANTHER; PTHR47977:SF72; RAS-RELATED PROTEIN RAB-44; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS51419; RAB; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 796..820
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 881..903
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 915..936
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 966..993
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1014..1037
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 812..1032
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 288..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1048..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 131..255
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 298..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1083 AA; 117273 MW; E24BC56EE705B580 CRC64;
MVELDVKKLE AKFSFLGGKE DPQMIFDWLD VERKGLLSLE EFSSGLQDIF GSSLSSQRLH
RKKPLPSKRV SVTTSFPALE EAEAEEKEEF FAFLEQLGTS HLLPEQAEIW QLWGKLRQEE
PALAGNLEGF LAKMNSRLRE VRADKEALEL TLKKRDSAHH HEVQQLYEEM EQQIRREKQQ
LQAESESRDL ALSSRMQEVL EAKEREVQQL AEGQRELEAQ LHRLSSTRQE ASSENQQLRE
AERDLAGRLE EVRGQLQVTK GHLSASRARV SWQMEEEPRQ VATIPGLGLQ TSDLDEKRPG
PVPAKPPRLR EVFHQDPRIT GPGSQEDTAL TPGPAEPSQG LEPVALAPME GLEQDEPGSA
VQEGHPGGAG DAHGLVLRPG GLPAVPHQSL EEEGKQLLPG GQNFSPDQSA EAHVEAGRSA
LPRHHAPSIP LSANTPPAQE EAPAPGKLSP PRASPPIGAQ LGAGAGPQEP TKTLPIKAEL
EARPPPKTMR AEEQAPPQLR EPGAEHRPVG PGTDSGEDPT VGKPQADPDY LFHIIFLGDS
NVGKTSFLHL LHQNSFAAGL TATVGVDFRI KNLLVDNKCF ALQLWDTAGQ ERETESESSL
PRGDGHTAIP SPPFSSQDFG HAQTRTRWNT LCVQDTGSDG VVLLLLGNKI DCEEERQVPT
EAGRQLAQEL GVSFGECSAV LGHNILEPMV NMARVLTHSR AERMPGKTVK ARVSVAPFSW
CHEEFRAAQS RGKEEQLCQG LWPFLLSKDS RISKQDLGTS EQHAAGGTAQ KDARSMEPNA
TFPAGLTVAA EHRLRLIFAG ICGLILLVGL LANGLMLLVV GRGPGAPRPL LALTNSLMVN
ITLSDLLFLA CVVPVLLLSF LRQNWWLGPA ICTVSQAANT ATMFCTFYSM VATALLRHVA
VAWPDVALPA SRGACLLLCG AMWILGLTAS LPNWLFQRVV VEEETSGAHG AQACLLLLSP
ARTSCYFTLL GALAFLPCVL GLGCSFSHVG WLLRSRPSGP AGESAREHYE NTRLILVVLV
VFVLMWGPCS VLGYVAAMGH WPATAPPASA PSWPTPIVPS APSSASTSPA PSGQDSGRCS
VGQ
//
