ID L9L1U7_TUPCH Unreviewed; 275 AA.
AC L9L1U7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Oxidoreductase HTATIP2 {ECO:0000256|ARBA:ARBA00039778};
GN ORFNames=TREES_T100000375 {ECO:0000313|EMBL:ELW67367.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW67367.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000256|ARBA:ARBA00004259}.
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DR EMBL; KB320618; ELW67367.1; -; Genomic_DNA.
DR RefSeq; XP_006146961.1; XM_006146899.2.
DR AlphaFoldDB; L9L1U7; -.
DR STRING; 246437.L9L1U7; -.
DR GeneID; 102492517; -.
DR KEGG; tup:102492517; -.
DR CTD; 10553; -.
DR eggNOG; KOG4039; Eukaryota.
DR InParanoid; L9L1U7; -.
DR OrthoDB; 150138at2759; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR CDD; cd05250; CC3_like_SDR_a; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR PANTHER; PTHR14097; OXIDOREDUCTASE HTATIP2; 1.
DR PANTHER; PTHR14097:SF7; OXIDOREDUCTASE HTATIP2; 1.
DR Pfam; PF13460; NAD_binding_10; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..275
FT /note="Oxidoreductase HTATIP2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004000046"
FT DOMAIN 53..154
FT /note="Semialdehyde dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00859"
SQ SEQUENCE 275 AA; 30143 MW; 85D54FC071CC4AC4 CRC64;
MRGPAALGGA AAVLVAALLL LGREDVGGGT GPSMAETEAL PKLREDFRMQ KKSVFILGAS
GETGRVLLKE ILEQSLFSKV TLIGRRKLTF DEEAYKNVNQ EIVDFEKLDD YASVFQGHDV
GFCCLGTTRK KAGAEGFVRV DRDYVLKSAE LAKAGGCKHF NLLSSKGADK SSSFLYLQVK
GEVEARIEEL KFDRYSIFRP GVLLCDRQES RPGEWLIRKF FSSIPDSWAS GHSVPVVTVV
RAMLNNAVKP SNEKMELLEN KAIHDLGKAD GSLKP
//
