ID L9L2E2_TUPCH Unreviewed; 511 AA.
AC L9L2E2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=U4/U6 small nuclear ribonucleoprotein Prp31 {ECO:0000256|ARBA:ARBA00013538};
DE AltName: Full=Pre-mRNA-processing factor 31 {ECO:0000256|ARBA:ARBA00030766};
GN ORFNames=TREES_T100011680 {ECO:0000313|EMBL:ELW69118.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW69118.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PRP31 family.
CC {ECO:0000256|ARBA:ARBA00005572}.
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DR EMBL; KB320547; ELW69118.1; -; Genomic_DNA.
DR AlphaFoldDB; L9L2E2; -.
DR STRING; 246437.L9L2E2; -.
DR eggNOG; KOG2574; Eukaryota.
DR InParanoid; L9L2E2; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IEA:InterPro.
DR Gene3D; 1.10.287.4070; -; 1.
DR Gene3D; 1.10.246.90; Nop domain; 1.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR InterPro; IPR027105; Prp31.
DR InterPro; IPR019175; Prp31_C.
DR PANTHER; PTHR13904; PRE-MRNA SPLICING FACTOR PRP31; 1.
DR PANTHER; PTHR13904:SF0; U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF09785; Prp31_C; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; Nop domain; 1.
DR PROSITE; PS51358; NOP; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW ECO:0000313|EMBL:ELW69118.1}; RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 246..364
FT /note="Nop"
FT /evidence="ECO:0000259|PROSITE:PS51358"
FT REGION 42..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..71
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 511 AA; 56749 MW; B71E762DD0EECDAC CRC64;
MGLESCLHGR EVRSARVKTQ GVRGVFHRAT GSRERDELLA DLEEAAEEEE GGSYGEEEEE
PTIEDVQEET QLDLSGDSVK SIAKLWDSKM FAEIMMKIEE YISKQAKASE VMGPVEAAPE
YRVIVDANNL TGEIENELNI IHKFIRDKYS KRFPELESLV PNALDYIRTV KELGNSLDKC
KNNENLQQIL TNATIMVVSV TASTTQGQQL SEEELERLEE ACDMALELNA SKHRIYEYVE
SRMSFIAPNL SIIIGASTAA KIMGVAGGLT TLSKMPACNI MLLGAQRRTL SGFSSTSVLP
HTGYVYHSDI VQSLPPDLRR KAARLVAAKC TLAARVDSFH ESTEGKVGYE LKDEIERKFD
KWQEPPPAKQ VKPLPAPLDG QRKKRGGRRY RKMKERLGLT EIRKQANRMS FGEIEEDAYQ
EDLGFSLGHL GKSGSGRRTL QKQSVVYGGK STIRDRTSGT ASSVAFTPLQ GLEIVNPQAA
EKKVAEANQK YFSSMAEFLK VKGEKSGILS T
//
