ID L9L360_TUPCH Unreviewed; 717 AA.
AC L9L360;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Brain-specific serine protease 4 {ECO:0000313|EMBL:ELW67832.1};
GN ORFNames=TREES_T100011832 {ECO:0000313|EMBL:ELW67832.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW67832.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB320600; ELW67832.1; -; Genomic_DNA.
DR AlphaFoldDB; L9L360; -.
DR STRING; 246437.L9L360; -.
DR MEROPS; S01.252; -.
DR eggNOG; KOG3627; Eukaryota.
DR InParanoid; L9L360; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd18390; BTB_POZ_KCTD5; 1.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.30.70.2000; -; 1.
DR Gene3D; 6.10.140.750; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR14958:SF12; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD5; 1.
DR PANTHER; PTHR14958; POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034, ECO:0000313|EMBL:ELW67832.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Serine protease {ECO:0000256|RuleBase:RU363034}.
FT DOMAIN 457..697
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 230..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 717 AA; 77029 MW; A50FCDD5AA94173D CRC64;
MAENHCELLP PAPGGLGAGL GGGLCRRCSA GLGALAQRPG SVSKWVRLNV GGTYFLTTRQ
TLCRDPKSFL YRLCQADPDL DSDKDETGAY LIDRDPTYFG PVLNYLRHGK LVVNKDLAEE
GVLEEAEFYN ITSLIKLVKD RIRERDSRTS QVPVKHVYRV LQCQEEELTQ MVSTMSDGWK
FEQLVSIGSS YNYGSEDQAE FLCVVSKELH TAPYGTASEP SEKAKVSAGL AAQGTLQEGK
PEPSPGQSYP EFGAGRARCH CLPPVHPSPR VSRQSHPSHV PALAFPEEMR CQGRGCSHLP
TASSTEDVPA WRCSGGPDRA QDRAGLGFLQ LPARSGVLGS CISPPQPALK HLHCTAGSLE
TASYLGTYTP PAMMVSRSPA ALRVGCLQLS VSLLLVCTVG FVPGQEVPGE ALEPWLPTLG
LPSWNGCSMG WRPEVSLGAA RTPAPPACGK PQQLNRIVGG QDSTDAEWPW VVSIQKNGTH
HCAGSLLTSR WVVTAAHCFK GSLNKPSQFS VLLGAWQLGN PGPRAQKVGI AWAHAHPVYS
WKEGAPADIA LVRLEHPVQF SERVLPICLP DASVHLPADT ACWIAGWGSI HEGVPLPQPQ
TLQKLKVPII DSEVCSRLYW RGAGQGAITE DMLCAGYLEG ERDACLGDSG GPLMCQVDGS
WLLAGVISWG EGCAERNRPG VYTSLTAHRP WVQRVVHGVQ LRGASGARGR GPWGLGS
//
