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Database: UniProt
Entry: L9L8R8_TUPCH
LinkDB: L9L8R8_TUPCH
Original site: L9L8R8_TUPCH 
ID   L9L8R8_TUPCH            Unreviewed;      1803 AA.
AC   L9L8R8;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   25-OCT-2017, entry version 30.
DE   SubName: Full=Sodium leak channel non-selective protein {ECO:0000313|EMBL:ELW71485.1};
GN   ORFNames=TREES_T100006237 {ECO:0000313|EMBL:ELW71485.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW71485.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB320462; ELW71485.1; -; Genomic_DNA.
DR   ProteinModelPortal; L9L8R8; -.
DR   InParanoid; L9L8R8; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   PANTHER; PTHR10037:SF214; PTHR10037:SF214; 2.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     79     99       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    105    122       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    188    205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    309    332       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    395    416       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    428    456       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    516    538       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    585    609       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    891    915       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    966    984       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1027   1050       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1154   1177       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1231   1251       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1257   1277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1298   1327       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1333   1355       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1420   1444       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       74    341       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      394    613       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      897   1182       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1229   1454       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      808    837       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1803 AA;  206546 MW;  19B44B64F84732E1 CRC64;
     MRTATAAAPG PGPPAAAWKP GAKVQTVVLY LLTKANFSML KRKQSSRVEA QPVTDFGPDE
     SLSDNADILW INKPWVHSLL RICAIISVIS VCMNTPMTFE HYPPLQYVTF TLDTLLMFLY
     TAEMIAKMHI RGIVKVFEIA DIVDQMSPWG MLRIPRPLIM IRAFRIYFRF ELPRTRITNI
     LKRSGEQIWS VSIFLLFFLL LYGILGVQMF GTFTYHCVVN DTKPGNVTWN SLAIPDTHCS
     PELEEGYQCP PGFKCMDLEN LGLSRQELGY SGFNEIGTSI FTVYEAASQE GWVFLMYRAI
     DSFPRWRSYF YFITLIFFLA WLVKNVFIAV IIETFAEIRV QFQQMWGSRS STTSTATTQM
     FHEDAAGGWQ LVAVDVNKPQ GRAPACLQKM MRSSVFHMFI LSMVTVDVIV AASNYYKGEN
     FRRQYDEFYL AEVAFTVLFD LEALLKIWCL GFTGYISSSL HKFELLLVIG TTLHVYPDLY
     HSQFTYFQVL RVVRLIKISP ALEDFVYKIF GPGKKLGSLV VFTASLLIVM SAISLQMFCF
     VEELDRFTTF PRAFMSMFQI LTQEGWVDVM DQTLNAVGHM WAPVVAIYFI LYHLFATLIL
     LSLFVAVILD NLELDEDLKK LKQLKQSEAN ADTKEKLPLR LRIFEKFPNR PQMVKISKLP
     SDFTVPKIRE SFMKQFIDRQ QQDTCCLLRS LPSTSSSSCD HSKRSAIEDN KYIDQKLRKS
     VFSIRARNLL EKETAVTKIL RACTRQRMLS GSFEGQPAKE RSILSVQHHI RQERRSLRHG
     SNSQRISRGK SLETLTQDHS NTVRYRNAQR EDSEIKMIQE KKEQAEMKRK VQEEELRENH
     PYFDKPLFIV GREHRFRNFC RVVVRARFNA SKTDPVTGAV KNTKYHQLYD LLGLVTYLDW
     VMIIVTICSC ISMMFESPFR RVMHAPTLQI AEYVFVIFMS IELNLKIMAD GLFFTPTAVI
     RDFGGVMDIF IYLVSLIFLC WMPQNVPAES GAQLLMVLRC LRPLRIFKLV PQMRKVVREL
     FSGFKEIFLV SILLLTLMLV FASFGVQLFA GKLAKCNDPN IIRREDCNGI FRINVSVSKN
     LNLKLRPGEK KPGFWVPRVW KIAMAYSELM ANPRNFNFDN VGNAMLALFE VLSLKGWVEV
     RDVIIHRVGP IHGIYIHVFV FLGCMIGLTL FVGVVIANFN ENKGTALLTV DQRRWEDLKS
     RLKIAQPLHL PPRPDNDGFR AKMYDITQHP FFKRTIALLV LAQSVLLSVK WDVEDPVTVP
     LATMSVVFTF IFVLEVTMKI IAMSPAGFWQ SRRNRYDLLV TSLGVVWVVL HFALLVTLKM
     LLLTVVVSMY KSFFIIVGMF LLLLCYAFAG VVLFGTVKYG ENINRHANFS SAGKAITVLF
     RIVTGEDWNK IMHDCMVQPP FCTPDEFTYW ATDCGNYAGA LMYFCSFYVI IAYIMLNLLV
     AIIVENFSLF YSTEEDQLLS YNDLRHFQII WNMVDDKREG VIPTFRVNLL RLLRGRLEVD
     LDKDKLLFKH MCYEMERLHN GGDVTFHDVL SSLRDKQSNN DEILDVSGKR GRTKLFSPPY
     GMRFSKEEKA DVPGSLEPLR CGLGSASRTD LTAGAVQGAD MLSYRSVDIR KSLQLEELLA
     REQLEYTIEE EVAKQTIRMW LKKCLKRIRA KQQQSCSIIH SLRVSQQQEL SRFLNPPSIE
     TTQPSEDINA NSQENNMQPE TSSQQQLLSP TLSDRGGSRQ DAGDAGKPQR KIGQWRLPSA
     PKPISHSVSS VNLRFGGRTT MKSVACKMNP MTDTASCGSE VKKWWTRQLT VESDESGDDL
     LDI
//
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