ID   L9L9T2_TUPCH            Unreviewed;       847 AA.
AC   L9L9T2;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Double-stranded RNA-specific editase B2 {ECO:0000313|EMBL:ELW71648.1};
GN   ORFNames=TREES_T100002464 {ECO:0000313|EMBL:ELW71648.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW71648.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
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DR   EMBL; KB320457; ELW71648.1; -; Genomic_DNA.
DR   AlphaFoldDB; L9L9T2; -.
DR   STRING; 246437.L9L9T2; -.
DR   InParanoid; L9L9T2; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd19896; DSRM_RED2_rpt1; 1.
DR   Gene3D; 3.30.160.20; -; 2.
DR   InterPro; IPR002466; A_deamin.
DR   InterPro; IPR044460; ADAR3_DSRM_1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   PANTHER; PTHR10910:SF17; DOUBLE-STRANDED RNA-SPECIFIC EDITASE B2; 1.
DR   PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR   Pfam; PF02137; A_deamin; 2.
DR   Pfam; PF00035; dsrm; 2.
DR   SMART; SM00552; ADEAMc; 1.
DR   SMART; SM00358; DSRM; 2.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR   PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR   PROSITE; PS50137; DS_RBD; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT   DOMAIN          114..180
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   DOMAIN          272..336
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   DOMAIN          457..843
FT                   /note="A to I editase"
FT                   /evidence="ECO:0000259|PROSITE:PS50141"
FT   REGION          42..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   847 AA;  93999 MW;  9087C077574BBF09 CRC64;
     MKALSFSETP CQSAFPVLLF FPDKMSMLST FLAPFKYLSP GTTNTEDEDN LSTSSAEVKE
     NRNVSNLGTR PPPPGDRARG STTSIKRKRP LEEGNGAHFC KLQLIWKKLS WSVTPKNALV
     QLHELKPGLQ YRMVSQTGPV HAPVFAVAVE VNGLTFEGTG PTKKKAKMRA AELALKSFVQ
     FPNACQAHLA MGSGVSPCTD FTSDQADFPD TLFKEFEPPA PSEGFPGCHP VDSELLSTAY
     RRGRLLYRTL DLMGQTRPDR PRPVPMVPGE RNPVVVLNEL RSGLRYVCLA EPAEKPRARS
     FVMAVCVDGR TFEGSGRSKK VAKGQAAQAA LQALFDIRLP GHTPSRSKSF LLPQSRLVNS
     LGGGSESQLL IILSLPGPVT SVVKKKNISS FLVRIKWDSE YTGSSMWWEF ADSVSQLVTQ
     KFRELTMGLT SVHARHKALA GIVMTKGLDT RQAQVIVLSS GTKCISGEHI NDQGLVVNDC
     HAEIVARRAF LHFLYAQLEL HLSKRREDSD RSIFMRLKEG GYRLRENILF HLYVSTSPCG
     DARLNSPYEI TTDRYALSAF IGGDRAESIH VPISPLNHHQ QRSVFQDWRT RVGLCFAVLD
     NISKAMIEER VEVNSTKHIV RKFRGHLRTK IESGEGTVPV RGPSAVQTWD GVLLGEQLIT
     MSCTDKIARW NVLGLQGALL CHFIEPVYLH SIIVGSLHHT GHLSRVMSHR MEDIGQLPAS
     YRHNRPLLSG VSNAEMRQPG KSPHFSVNWA VGNADLEIID ATTGKRICGG SSRLCKRVFS
     ARWARLHGRL STRIPHHGDT PTMYCEAKLG AQTYQAVKQQ LFKAFQKAGL GMWVRKPPEQ
     DQFLLTL
//