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Database: UniProt
Entry: L9LAV7_TUPCH
LinkDB: L9LAV7_TUPCH
Original site: L9LAV7_TUPCH 
ID   L9LAV7_TUPCH            Unreviewed;      2216 AA.
AC   L9LAV7;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-SEP-2017, entry version 22.
DE   RecName: Full=Voltage-dependent R-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=TREES_T100015810 {ECO:0000313|EMBL:ELW70887.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW70887.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1E
CC       gives rise to R-type calcium currents. R-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA).
CC       They are however insensitive to dihydropyridines (DHP), omega-
CC       conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-
CC       Aga-IVA). Calcium channels containing alpha-1E subunit could be
CC       involved in the modulation of firing patterns of neurons which is
CC       important for information processing.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; KB320481; ELW70887.1; -; Genomic_DNA.
DR   ProteinModelPortal; L9LAV7; -.
DR   InParanoid; L9LAV7; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF253; PTHR10037:SF253; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01633; RVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011518};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     59     77       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     97    117       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    129    147       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    188    210       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    262    283       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    295    317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    426    446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    452    470       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    552    574       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    629    652       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1081   1100       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1153   1170       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1214   1236       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1326   1351       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1407   1425       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1437   1460       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1466   1484       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1531   1549       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1624   1648       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1785   1819       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      648    675       {ECO:0000256|SAM:Coils}.
FT   COILED     1029   1054       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2216 AA;  250620 MW;  3BA3BE7F4B27A730 CRC64;
     MSLHRRERLR PSLVNIFLNS SFPTPFEYMI LATIIANCIV LALEQHLPED DKTPMSRRLY
     MILATIIANC IVLALEQHLP EDDKTPMSRR LEKTEPYFIG IFCFEAGIKI VALGFIFHKG
     SYLRNGWNVM DFIVVLSGIL ATAGTHFNTH VDLRTLRAVR VLRPLKLVSG IPSLQIVLKS
     IMKAMVPLLQ IGLLLFFAIL MFAIIGLEFY SGKLHRACFM NNSGILEGFD PPHPCGVQGC
     PAGYECKDWI GPNDGITQFD NILFAVLTVF QCITMEGWTT VLYNTNDALG ATWNWLYFIP
     LIIIGSFFVL NLVLGVLSGE FAKERERVEN RRAFMKLRRQ QQIERELNGY RAWIDKAVLR
     RATIKRSRTE AMTRDSSDEH CVDISSVGTP LARASIKSTK VDGASYFRHK ERLLRISIRH
     MVKSQVFYWI VLSLVALNTA CVAIVHHNQP QWLTHLLYYA EFLFLGLFLL EMSLKMYGMG
     PRLYFHSSFN CFDFGVTVGS IFEVVWAIFR PGTSFGISVL RALRLLRIFK ITKYWASLRN
     LVVSLMSSMK SIISLLFLLF LFIVVFALLG MQLFGGRFNF NDGTPSANFD TFPAAIMTVF
     QILTGEDWNE VMYNGIRSQG GVSSGMWSAI YFIVLTLFGN YTLLNVFLAI AVDNLANAQE
     LTKDEQEEEE AFNQKHALQK AKEVSPMSAP NMPSIERERR RRHHMSVWEQ RTSQLRRHMQ
     MSSQEALNKE EAPPMNPLNP LNPLSPLNPL NAHPSLYRRP RPIEGLALGL GLEKCEEERI
     SRGGSLKGDS GDLSSVLDNQ RSPLALGKRE PPWLARPCHG NCDPTQQEAG GGETVVTFED
     RARHRQSQRR SRHRRVRTEG KESASASRSR SASQERSLDE GVLPEGEKDH DPRGSHGGKE
     PTIQEERAQD LRRTNSLMVP RGSGLAGALD EADTPLVLPH PELEVGKDAV LTEQEPEGSS
     EQALLGDVPL DVGRAISQSE PDLSCITATT DKATTESTSV AVAIPDVGPL VDSTVVHISN
     KTDGEASPLK EAEIKEDEEE VEKKKKKEKR ETGKAMVPHS SMFIFSTTNP IRRACHYIVN
     LRYFEMCILL VIAASSIALA AEDPVLTNSE RNKVLRYFDY VFTGVFTFEM VIKMIDQGLI
     LQDGSYFRDL WNILDFVVVV GALVAFALAT NKGRDIKTIK SLRVLRVLRP LKTIKRLPKL
     KAVFDCVVTS LKNVFNILIV YKLFMFIFAV IAVQLFKGKF FYCTDSSKDT EKECIGNYVD
     HEKNKMEVKG REWKRHEFHY DNIIWALLTL FTVSTGEGWP QVLQHSVDVT EEDRGPSRSN
     RMEMSIFYVV YFVVFPFFFV NIFVALIIIT FQEQGDKMME ECSLEKNERA CIDFAISAKP
     LTRYMPQNRH TFQYRVWHFV VSPSFEYTIM AMIALNTVVL MMKYYSAPCT YELALKYLNI
     AFTMVFSLEC VLKIIAFGFL NYFRDTWNIF DFITVIGSIT EIILTDSKLV NTSGFNMSFL
     KLFRAARLIK LLRQGYTIRI LLWTFVQSFK ALPYVCLLIA MLFFIYAIIG MQVFGNIKLD
     EESHINRHNN FRSFFGSLML LFRSATGEAW QEIMLSCLGE KGCEPDTTAP SGQNENERCG
     TDLAYVYFVS FIFFCSFLML NLFVAVIMDN FEYLTRDSSI LGPHHLDEFV RVWAEYDRAA
     CGRIPYKDMY KLVRVISPPL GLGENCPYRV ACKRLVLMNM PVAEDMTVHF TSTLMALIRT
     ALDIKIAKGG ADRQQLDSEL QKETLAIWPH LSQKMLDLLV PMPKASDLTV GKIYAAMMIM
     DYYKQSKVKK QRQQLEEQKN APMFQRMEPS SLPQEIIANA KALPYLQQDP VSGLSGRSGY
     PSMSPLSPQE IFQLACMDPN DDGQFQEQQS LEPEVSELKS VQSSSHGIYL PSETQEHAGS
     GRASSMPRLT VDPQVVTDPS SMRRSFSTIR DKRSNSSWLE EFSMERSSEN TYKSRRRSYH
     SSLRLSAHRL NSDSGHKSDT HRSGGRERGR SKERKHLLSP DVSRCNSEER GTQADWESPE
     RRQSRSPSEG RSQTPNRQGT GSLSESSIPS ISDTSTPRRS RRQLPPVPPK PRPLLSYSSL
     IRHAGSISPP ADGSEGGSPL ASQALESNSA CLTESSNSPH PQQGQHSSPQ RYISEPYLAL
     HEDSHASDCG EEETLTFEAA MPNGHYRRRR RGGPGPGMMC GAVSDLLSDT EEDDKC
//
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