ID L9W0Z1_9EURY Unreviewed; 1026 AA.
AC L9W0Z1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=D-lactate dehydrogenase (Cytochrome) {ECO:0000313|EMBL:ELY43125.1};
GN ORFNames=C494_19037 {ECO:0000313|EMBL:ELY43125.1};
OS Natronorubrum bangense JCM 10635.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natronorubrum.
OX NCBI_TaxID=1227500 {ECO:0000313|EMBL:ELY43125.1, ECO:0000313|Proteomes:UP000011690};
RN [1] {ECO:0000313|EMBL:ELY43125.1, ECO:0000313|Proteomes:UP000011690}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 10635 {ECO:0000313|EMBL:ELY43125.1,
RC ECO:0000313|Proteomes:UP000011690};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELY43125.1}.
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DR EMBL; AOHY01000058; ELY43125.1; -; Genomic_DNA.
DR RefSeq; WP_006067921.1; NZ_AOHY01000058.1.
DR AlphaFoldDB; L9W0Z1; -.
DR STRING; 1227500.C494_19037; -.
DR GeneID; 39852780; -.
DR PATRIC; fig|1227500.6.peg.3844; -.
DR eggNOG; arCOG00337; Archaea.
DR OrthoDB; 2837at2157; -.
DR Proteomes; UP000011690; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProt.
DR Gene3D; 3.30.465.10; -; 2.
DR Gene3D; 3.30.70.2740; -; 1.
DR Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR004017; Cys_rich_dom.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR009051; Helical_ferredxn.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR PANTHER; PTHR11748:SF119; D-2-HYDROXYGLUTARATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR Pfam; PF02754; CCG; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13183; Fer4_8; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
FT DOMAIN 60..303
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT DOMAIN 670..703
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1026 AA; 111907 MW; DB07F60B70146227 CRC64;
MTITPPNRLD PADDPEANYN YQSDDIERPD LLADLEARVD GDVRFDSYSR QLYATDASIY
EVTPIGVVFP TSTDDVASVV SYCADNEIPV LPRGGGTSLA GQTVNEAVVL DFTTYMDDVV
DIDPDARRAT AQTGIYLGSF NEALAPHELK FAPDPAWGDK SALGGAIGNN TTGAHSLQYG
KTDAYVEEVE VVLADGTVTT FGEVDLEDVP ELADGDDLES AIYAEVARIL EEQGDLIDDV
YPDLKRNVSG YNLDWLVEDA YGGERGIGEP DSEGGTINLA KLLCGSEGTL AIVTEATVSL
ETIPEEKSMA LLAYDSVLEA MDDVEPIVEH DPAAVEVLDD VMIDLARDTP EFAPVTEMLP
DGTAAVLIVE FYADDVDDGK RKVANLLADR CPSVESEGEA DDEDERTITG ADTLAFDAIE
AYDADSRAKI WKLRKSGLPI LLSRTTDEKH VAFIEDTGIP PANLRAFVAD FQEVLEDHDT
YASFYAHAGP GVLHIRPLVN TKTDAGLEDM ESITDAVTDL VVKYDGSVSG EHGDGRARTQ
WNRKLYGEAV WETFQELKTA FDPDWLLNPG QVVYRDDDPT DMTKNHRFGP DYEFNAGFEP
ALEWDNDQGF QGMTELCHGC GGCRGEQSTT GGVMCPTFRA EDEEILSTRG RANMLRQAMS
GELEPDEQFD DEFVEEVLDL CIGCKGCKHD CPSGVDMAKL KAELTYEHHK RNGVSLRDQF
FTNFETLAKL GSATAPVSNW MAKLPGSGVL TEKLLGISRE RDLPTFQRNT FAKRVADHRP
AVPAREADRR VVLVPDIYTN HEYPEAGEAA LAVLEAAGVH VEIADPRDVG RPAYSKGLLG
QAAEDATDTV HELLPYVEDG YDVVLIEPSD AVMVQSDYLD LFDHPEVEAV ATNTYGVCEY
IDQFDLDADI EFAAPDEHLA YHGHCHQKAH AKDHHAVGVL RRAGYAVDPL DSTCCGMAGS
FGYEVEHYSM SKAIGEVLYE QVDDSTAERV VAPGASCRTQ LEDRPGATEK PPTPIEVVAA
ALAGRR
//
