ID   L9WJR0_9EURY            Unreviewed;       399 AA.
AC   L9WJR0;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=Peptidase M24 {ECO:0000313|EMBL:ELY49612.1};
GN   ORFNames=C495_00245 {ECO:0000313|EMBL:ELY49612.1};
OS   Natronorubrum sulfidifaciens JCM 14089.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natronorubrum.
OX   NCBI_TaxID=1230460 {ECO:0000313|EMBL:ELY49612.1, ECO:0000313|Proteomes:UP000011661};
RN   [1] {ECO:0000313|EMBL:ELY49612.1, ECO:0000313|Proteomes:UP000011661}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 14089 {ECO:0000313|EMBL:ELY49612.1,
RC   ECO:0000313|Proteomes:UP000011661};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|RuleBase:RU000590}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ELY49612.1}.
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DR   EMBL; AOHX01000001; ELY49612.1; -; Genomic_DNA.
DR   RefSeq; WP_008158854.1; NZ_AOHX01000001.1.
DR   AlphaFoldDB; L9WJR0; -.
DR   STRING; 1230460.C495_00245; -.
DR   PATRIC; fig|1230460.4.peg.52; -.
DR   eggNOG; arCOG01000; Archaea.
DR   OrthoDB; 1346at2157; -.
DR   Proteomes; UP000011661; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd01092; APP-like; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR   PANTHER; PTHR46112; AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR46112:SF3; AMINOPEPTIDASE YPDF; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR   PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000590};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011661}.
FT   DOMAIN          8..156
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          166..378
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
SQ   SEQUENCE   399 AA;  43352 MW;  F35A17A8B9145F92 CRC64;
     MDAPFATRIR DCKRRLEDVD AALLICFPSP NLTYLTGFEE TPSERHLLLF VPRTGDPVFV
     APAMYDQQLA SLPLDCRFWN DGDDPVELVD DVLEEILDQP RGERQTTARD SADRSTADDT
     TLLVDDRLWA TFSQDLRACV PNATFGLAST VLEEVRIRKD ARELDALRRA GAVADRVSLE
     VRSRGEDLIG MSERELAGEI ERLLASAGGG EPAFSTIVAS GPNGARPHHH SSDRPIEVGD
     PIVLDFGAFV AADLEGGTGR YPGDQTRTMV VGEPPAKYRQ VHETVLHAQQ AAIDAVEPGV
     TAGSIDRAAR SVIEDAGYGD AFVHRTGHGV GLEVHEPPYI VDGNDRELEP GMVFSVEPGI
     YLEGEFGVRI EDLVVVTDDG AERLNDSPRG WATGSVGEQ
//