ID   L9WNB6_9EURY            Unreviewed;      1289 AA.
AC   L9WNB6;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=C494_07505 {ECO:0000313|EMBL:ELY49838.1};
OS   Natronorubrum bangense JCM 10635.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natronorubrum.
OX   NCBI_TaxID=1227500 {ECO:0000313|EMBL:ELY49838.1, ECO:0000313|Proteomes:UP000011690};
RN   [1] {ECO:0000313|EMBL:ELY49838.1, ECO:0000313|Proteomes:UP000011690}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10635 {ECO:0000313|EMBL:ELY49838.1,
RC   ECO:0000313|Proteomes:UP000011690};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ELY49838.1}.
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DR   EMBL; AOHY01000016; ELY49838.1; -; Genomic_DNA.
DR   RefSeq; WP_006065664.1; NZ_AOHY01000016.1.
DR   STRING; 1227500.C494_07505; -.
DR   GeneID; 39852356; -.
DR   PATRIC; fig|1227500.6.peg.1518; -.
DR   eggNOG; arCOG04814; Archaea.
DR   OrthoDB; 170702at2157; -.
DR   Proteomes; UP000011690; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:0034641; P:cellular nitrogen compound metabolic process; IEA:UniProt.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR046816; MmeI_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF20473; MmeI_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          504..592
FT                   /note="MmeI-like DNA-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF20473"
SQ   SEQUENCE   1289 AA;  149533 MW;  7DB1C59FA44DCA48 CRC64;
     MSEESFQPEF DIEEFETQVS RKDEDRIIEA IAQSVRNLRD QIDDDILDET FSRGRGEYVL
     KTKYTKDRLD PEPTTKDRVI EPLLDELGYE DYGYEAGSFS TTRGEQADYA VSLRDISGVD
     SSRLLIEAEP LKKRLEGRGH GLDQVKSWLS QREFESDFGF ATDGLVWIFV RYDPDSYTHN
     IISRVDLQPV FRTLYENQTT RQDPPLEVVS DEDRERIAEL IRTFDFQNFC SIIDDAQEVI
     KRKQKEITGE FYDDYIKYVF GVAEGEEERR ARSLVGDGVD APPDATGDDT RLFSVDLMNR
     LIFIKFLEDK RIVQPGLLST LAETYDPSIH PQSLYKTYLD PLFYEVLNKK EEDRSAQVEN
     IEFYNDIPYL NGGLFRPDLG TENDVDEREF DVQDSVLMSI IELLEQYQFS TDGGPTDIDP
     SVLGSVFEKT INYLTTDPGD QNADLGAYYT PKEITRFSAE QTVRPALKEQ LQETLIEERD
     WPEAEVNQYE TIYELIDDLP GSTNLITRLL SDIDELYVVD PSMGSGHFLT SVVEEITNIR
     QELWAKTEEY PNRHRVKRTT VQNNIYGVDI MEPAVEIGKL RLWLSIIAEL EEADVEELNT
     EELALPNITF NVRQGNSLIG YVGFPEETED GLSTFERWTE DSVRSRYEDV IEEIELYEEY
     KAFPEKSEKH RQNALELLEQ YREELDDDIL NDFQDVVENV TQDDLDNYTP FHWVLEFAEV
     YADGGFDVIV GNPPWDRLRP TRDDYFVRYD EEFPSLLPEE KEQRQSVLLD DPEINEGWEQ
     YNHEIEVVTE YFHKSGEYQM QKPTIGGTTQ GTENDLSSLF LERIFQLTKE GGYVSQVLPG
     MVFGGAANKD LRTHLLDGTT IESLVTFENK GIVFPEIHDQ FNFGVVVFQN SGRTDELKGI
     FQQVGMDVLG DFENKALRIT RQALREYSPE ARIFPQLQSQ EEVEVLDTIV QYPPIGEEQE
     DCWYAKPYAE LHRTNDTDRF VEDQSKGDYP VYQGSNIYQF IYDSTFFDVE PPEFWSVEEE
     VDSELSAKAR IRQKNKRKLK KALFTAFDGS GSQVQFVNNL LEDHRGSELS EDDVLLDCTE
     YRIVFRDITK FSNERTIVAS VIPPEVVCTN TLHTIRPYEI NPVEDDLSSE PLHSVYDRIF
     TDESLFAALG LINSVPFDYL MRTKINTHIQ KYKFVESQVP RLTKGDEWFE HIWTRAARLN
     CYGEKFEEMQ ERLGGIEPVI EEPERRETQA ELDAAAFHAY GLNRKQTAFI LEDFYQVQNP
     RLMDDKYLEM VLNKYEELAE QKEEDRATA
//