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Database: UniProt
Entry: L9YXU6_9EURY
LinkDB: L9YXU6_9EURY
Original site: L9YXU6_9EURY 
ID   L9YXU6_9EURY            Unreviewed;       815 AA.
AC   L9YXU6;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   SubName: Full=Hef nuclease {ECO:0000313|EMBL:ELY78939.1};
GN   ORFNames=C487_06925 {ECO:0000313|EMBL:ELY78939.1};
OS   Natrinema pallidum DSM 3751.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natrinema.
OX   NCBI_TaxID=1227495 {ECO:0000313|EMBL:ELY78939.1, ECO:0000313|Proteomes:UP000011618};
RN   [1] {ECO:0000313|EMBL:ELY78939.1, ECO:0000313|Proteomes:UP000011618}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 3751 {ECO:0000313|EMBL:ELY78939.1,
RC   ECO:0000313|Proteomes:UP000011618};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ELY78939.1}.
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DR   EMBL; AOII01000041; ELY78939.1; -; Genomic_DNA.
DR   RefSeq; WP_006184951.1; NZ_AOII01000041.1.
DR   AlphaFoldDB; L9YXU6; -.
DR   PATRIC; fig|1227495.3.peg.1387; -.
DR   eggNOG; arCOG00872; Archaea.
DR   OrthoDB; 9764at2157; -.
DR   Proteomes; UP000011618; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd12089; Hef_ID; 1.
DR   CDD; cd20075; XPF_nuclease_XPF_arch; 1.
DR   Gene3D; 3.40.50.10130; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 1.20.1320.20; hef helicase domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR006166; ERCC4_domain.
DR   InterPro; IPR041755; Hef_ID.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR010994; RuvA_2-like.
DR   PANTHER; PTHR14025; FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER; 1.
DR   PANTHER; PTHR14025:SF20; FANCONI ANEMIA GROUP M PROTEIN; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF02732; ERCC4; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF14520; HHH_5; 1.
DR   Pfam; PF21210; RNA_helicase_helical; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00891; ERCC4; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00278; HhH1; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          30..197
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          361..528
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          318..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          520..600
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   815 AA;  90032 MW;  93F1B768AD9AADD8 CRC64;
     MAAQDEDVAS IEHPLLEPDF LERRLYQLKL AGTAANHHTL VCLPTGLGKT TVSLLVTARR
     LEEVGGRALM LAPTKPLVQQ HADFYREALQ IPDEEIVVFT GDVSPDDRAA TWESATVVMA
     TPQVIENDLV GSRISLADVT HVTFDECHRA TGDYAYNYIA ERYHADAKRP LVTGMSASPG
     GDEEAILEVC ENLGIDEVEV MTEEDADVDE FTHDTEVEWE RIDLPDEVLE IRDALHEVIT
     ERLEKLKELG VASSTQPDQS QKDLNRMRAE LQTLINNDQS EGFEGMSIHA EVMKLRQAVT
     LVETQSVEAL RRYFERQRNQ ARTSGASKAS QRMVSDPRVR EAMRKAESFD EIHPKYRRAR
     VLLAETLGLE GGERVIVFTE SRDTAEALTD FLSDSFDTKR FVGQGDREGS DGMTQKQQQA
     VLDEFRAGEF EVLVSTSVAE EGLDVPEVDL VLFYEPVPTA IRSIQRKGRT GRQTEGRVVV
     LMAEDTRDEA YFWISRRREK EMESELRELK GLAPEIAEEL DDSQQSLTDF EGAGEGGVKV
     DGNDEHTDAV GDSSSGSEGV AAGPGLQAFG ERNSETGSDQ DTGDEADEIE THEPHADGDT
     VAVVADQREM DANIARDLSR REEYEISLET LDVGDYVLSD RVVVERKSVA DFVDSLVGGD
     RSVFEQVGAM ARHYSRPIVV IEGEGLYEQR DVHPNAVRGA LSSLAVDFGA SVLRTDDEDD
     TTELLAVIAG REQETADREV SVHGEKGTKT LREQQEYVVS SIAEIGPVTA RSLLEEFGTV
     EAVMIATEDE LQEADGVGTV TAERIREVIG SDYTG
//
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