ID L9YXU6_9EURY Unreviewed; 815 AA.
AC L9YXU6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Hef nuclease {ECO:0000313|EMBL:ELY78939.1};
GN ORFNames=C487_06925 {ECO:0000313|EMBL:ELY78939.1};
OS Natrinema pallidum DSM 3751.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrinema.
OX NCBI_TaxID=1227495 {ECO:0000313|EMBL:ELY78939.1, ECO:0000313|Proteomes:UP000011618};
RN [1] {ECO:0000313|EMBL:ELY78939.1, ECO:0000313|Proteomes:UP000011618}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3751 {ECO:0000313|EMBL:ELY78939.1,
RC ECO:0000313|Proteomes:UP000011618};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELY78939.1}.
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DR EMBL; AOII01000041; ELY78939.1; -; Genomic_DNA.
DR RefSeq; WP_006184951.1; NZ_AOII01000041.1.
DR AlphaFoldDB; L9YXU6; -.
DR PATRIC; fig|1227495.3.peg.1387; -.
DR eggNOG; arCOG00872; Archaea.
DR OrthoDB; 9764at2157; -.
DR Proteomes; UP000011618; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd12089; Hef_ID; 1.
DR CDD; cd20075; XPF_nuclease_XPF_arch; 1.
DR Gene3D; 3.40.50.10130; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 1.20.1320.20; hef helicase domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR006166; ERCC4_domain.
DR InterPro; IPR041755; Hef_ID.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR14025; FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER; 1.
DR PANTHER; PTHR14025:SF20; FANCONI ANEMIA GROUP M PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF02732; ERCC4; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF21210; RNA_helicase_helical; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00891; ERCC4; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00278; HhH1; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 30..197
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 361..528
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 318..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 90032 MW; 93F1B768AD9AADD8 CRC64;
MAAQDEDVAS IEHPLLEPDF LERRLYQLKL AGTAANHHTL VCLPTGLGKT TVSLLVTARR
LEEVGGRALM LAPTKPLVQQ HADFYREALQ IPDEEIVVFT GDVSPDDRAA TWESATVVMA
TPQVIENDLV GSRISLADVT HVTFDECHRA TGDYAYNYIA ERYHADAKRP LVTGMSASPG
GDEEAILEVC ENLGIDEVEV MTEEDADVDE FTHDTEVEWE RIDLPDEVLE IRDALHEVIT
ERLEKLKELG VASSTQPDQS QKDLNRMRAE LQTLINNDQS EGFEGMSIHA EVMKLRQAVT
LVETQSVEAL RRYFERQRNQ ARTSGASKAS QRMVSDPRVR EAMRKAESFD EIHPKYRRAR
VLLAETLGLE GGERVIVFTE SRDTAEALTD FLSDSFDTKR FVGQGDREGS DGMTQKQQQA
VLDEFRAGEF EVLVSTSVAE EGLDVPEVDL VLFYEPVPTA IRSIQRKGRT GRQTEGRVVV
LMAEDTRDEA YFWISRRREK EMESELRELK GLAPEIAEEL DDSQQSLTDF EGAGEGGVKV
DGNDEHTDAV GDSSSGSEGV AAGPGLQAFG ERNSETGSDQ DTGDEADEIE THEPHADGDT
VAVVADQREM DANIARDLSR REEYEISLET LDVGDYVLSD RVVVERKSVA DFVDSLVGGD
RSVFEQVGAM ARHYSRPIVV IEGEGLYEQR DVHPNAVRGA LSSLAVDFGA SVLRTDDEDD
TTELLAVIAG REQETADREV SVHGEKGTKT LREQQEYVVS SIAEIGPVTA RSLLEEFGTV
EAVMIATEDE LQEADGVGTV TAERIREVIG SDYTG
//