ID LET12_SOLLC Reviewed; 426 AA.
AC O22300;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE RecName: Full=Homeobox protein knotted-1-like LET12;
GN Name=LET12;
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. VFNT Cherry;
RX PubMed=9484482; DOI=10.1023/a:1005925508579;
RA Janssen B.-J., Williams A., Chen J.J., Mathern J., Hake S., Sinha N.;
RT "Isolation and characterization of two knotted-like homeobox genes from
RT tomato.";
RL Plant Mol. Biol. 36:417-425(1998).
CC -!- FUNCTION: May have a role to play in formative events in ovule and
CC embryo morphogenesis.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed in the mature plant.
CC -!- SIMILARITY: Belongs to the TALE/KNOX homeobox family.
CC {ECO:0000255|PROSITE-ProRule:PRU00559}.
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DR EMBL; AF000142; AAC49918.1; -; mRNA.
DR PIR; T04318; T04318.
DR AlphaFoldDB; O22300; -.
DR SMR; O22300; -.
DR STRING; 4081.O22300; -.
DR PaxDb; 4081-Solyc07g007120-2-1; -.
DR eggNOG; KOG0773; Eukaryota.
DR InParanoid; O22300; -.
DR Proteomes; UP000004994; Unplaced.
DR ExpressionAtlas; O22300; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR005539; ELK_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR005540; KNOX1.
DR InterPro; IPR005541; KNOX2.
DR PANTHER; PTHR11850:SF358; HOMEOBOX PROTEIN KNOTTED-1-LIKE 13; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF03789; ELK; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF03790; KNOX1; 1.
DR Pfam; PF03791; KNOX2; 1.
DR SMART; SM01188; ELK; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM01255; KNOX1; 1.
DR SMART; SM01256; KNOX2; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51213; ELK; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..426
FT /note="Homeobox protein knotted-1-like LET12"
FT /id="PRO_0000048974"
FT DOMAIN 327..347
FT /note="ELK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00559"
FT DNA_BIND 348..411
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 426 AA; 47581 MW; 5B52B9E0A34A86BC CRC64;
MEFQDHFSQE MVLHQQQQQQ QQQQNAVLRS MLPESPHHDA RKSPPTWLNT SLLRQQHSQF
GNASSPSSAA AAAAVAGGNN FLHLQTSNSD SSNSNQWLSP TAAAGGGSNG GGSGHNDELS
ESMNFAKKMS QQHSGGGEEN NNNNNNNNNN NNEEENSWER EKCKADILNH PLYDQLLSAH
VSCLRIATPV DQLPRIDAQL AQSQNVVAKY SVLGQGQPPL DDKDLDQFMT HYVLLLSSFK
EQLQQHVRVH AMEAVMACWE LEQSLQSLTG VAPGEGTGAT MSDDDDDQAD SDTNFLDGGF
DGPDSMGFGP LVPTESERSL MERVRQELKH ELKQGYKEKI VDIREEILRK RRAGKLPGDT
TSVLKAWWQS HSKWPYPTEE DKARLVQETG LQLKQINNWF INQRKRNWHS NPSTSSSQKS
QTQECR
//
