ID LMBD1_NEMVE Reviewed; 546 AA.
AC A7RM45;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=Probable lysosomal cobalamin transporter;
GN ORFNames=v1g160387;
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6;
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC cobalamin from lysosomes allowing its conversion to cofactors (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC {ECO:0000305}.
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DR EMBL; DS469519; EDO47438.1; -; Genomic_DNA.
DR RefSeq; XP_001639501.1; XM_001639451.1.
DR AlphaFoldDB; A7RM45; -.
DR SMR; A7RM45; -.
DR STRING; 45351.A7RM45; -.
DR EnsemblMetazoa; EDO47438; EDO47438; NEMVEDRAFT_v1g160387.
DR KEGG; nve:5519625; -.
DR eggNOG; ENOG502QQ2T; Eukaryota.
DR HOGENOM; CLU_028341_1_0_1; -.
DR InParanoid; A7RM45; -.
DR OMA; FWAQFVF; -.
DR OrthoDB; 8533at2759; -.
DR PhylomeDB; A7RM45; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR GO; GO:0072665; P:protein localization to vacuole; IBA:GO_Central.
DR CDD; cd14686; bZIP; 1.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR PANTHER; PTHR16130:SF2; LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1; 1.
DR PANTHER; PTHR16130; LYSOSOMAL COBALAMIN TRANSPORTER-RELATED; 1.
DR Pfam; PF04791; LMBR1; 1.
PE 3: Inferred from homology;
KW Cobalamin; Cobalt; Glycoprotein; Lysosome; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..546
FT /note="Probable lysosomal cobalamin transporter"
FT /id="PRO_0000365833"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 444
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 452
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 459
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 546 AA; 62686 MW; A8133D0470B83A54 CRC64;
MTIPHEVLAQ GWIPFTVVVV LAILFSWFYI RYYQDHSQSE VSSTITGIIA LFIALMTTAL
VPVDIFLVSY MKNDDGSWKP WSANRMNRDD IEETAVATTY YILYALLAFF VFVIIPFMYF
FFEERDEDIT TAERACGALK YSIGFLIVAS VLLLVGAFAP LKQPPKNVTE WDKRLIFLKD
ELKSNNGETA LSLLIGFLTL IGMLIMITYT AYGMTALPFS LLKGFKSAKT EQESVTRRRS
RNQEQARLIK AQYMGGRAMS SRDRRRLSEL EKEEHALATR ERRLEAAQLG WLNKCLKLLR
PFEMVFGAFF LLVALLIFVS LFITCLDKAL HSNGYQYGYS LPTPQLPNPI NIIMVYAQIV
FPLDYCLFLL VVLYFVYSSM AGIRRVGIRC CWIKLFKVRP RRTLPQALLF MCVMLMLIVL
SLNVMLFSLA PQYVMYGSQN YRANSTVTSL VNHTGIIQNV TTSHGIAKVC SMEMSSDHCT
MTRIAVFLNR FFYKVWFFGA CYYWGTWLFL VVFMTGLIYS IVRKRKTVVD EEYDSSDDSD
EEMVTA
//
